2-(Cyclohexyloxy)-5-nitropyridine

Base Information

• Chemical Name: 2-(Cyclohexyloxy)-5-nitropyridine
• CAS No.: 85003-00-5
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.244
• DSSTox Substance ID: DTXSID60510978
• Wikidata: Q82369572
• Mol file: 85003-00-5.mol

Synonyms:2-(Cyclohexyloxy)-5-nitropyridine;85003-00-5;2-cyclohexyloxy-5-nitropyridine;DTXSID60510978;AKOS027257472;DS-10505;CS-0155318;F52119;A923220

Chemical Property of 2-(Cyclohexyloxy)-5-nitropyridine

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 222.10044231
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

97% ^*data from raw suppliers

2-(Cyclohexyloxy)-5-nitropyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)OC2=NC=C(C=C2)[N+](=O)[O-]

Technology Process of 2-(Cyclohexyloxy)-5-nitropyridine

There total 2 articles about 2-(Cyclohexyloxy)-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.7%

2-(morpholin-4-yl)ethanol (622-40-2) + cyclohexanol (108-93-0) → 2-cyclohexyloxy-5-nitro-pyridine (85003-00-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1248/cpb.30.3580

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) + sodium cyclohexanolate (22096-22-6) → 2-cyclohexyloxy-5-nitro-pyridine (85003-00-5)

Guidance literature:

With cyclohexanol;

DOI:10.1021/ja01197a063

Reference yield:

2-cyclohexyloxy-5-nitro-pyridine (85003-00-5) → 6-(cyclohexyloxy)pyridin-3-amine (224187-22-8)

Guidance literature:

With methanol; iron; acetic acid;

DOI:10.1021/ja01197a063

upstream raw materials:

2-chloro-5-nitropyridine

sodium cyclohexanolate

2-(morpholin-4-yl)ethanol

cyclohexanol

Downstream raw materials:

6-(cyclohexyloxy)pyridin-3-amine

5-(6-Cyclohexyloxy-pyridin-3-ylmethyl)-thiazolidine-2,4-dione

2-Chloro-3-(6-cyclohexyloxy-pyridin-3-yl)-propionic acid methyl ester