N-benzyl-2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide

Base Information

• Chemical Name: N-benzyl-2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide
• CAS No.: 55654-78-9
• Molecular Formula: C₂₄H₂₀N₂O₂
• Molecular Weight: 368.435
• Mol file: 55654-78-9.mol

Synonyms:N-benzyl-2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide

Chemical Property of N-benzyl-2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide

There total 3 articles about N-benzyl-2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide (108977-91-9) + benzyl bromide (100-39-0) → N-benzyl-2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide (55654-78-9)

Guidance literature:

2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; for 24h;

DOI:10.1016/j.ejmech.2013.09.001

Reference yield:

indole (120-72-9) → N-benzyl-2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide (55654-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diethyl ether / 20 °C

2.1: triethylamine / toluene / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3.2: 24 h

With sodium hydride; triethylamine; In diethyl ether; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1016/j.ejmech.2013.09.001

Reference yield:

indolyl-3-glyoxylyl chloride (22980-09-2) → N-benzyl-2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide (55654-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / toluene / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 24 h

With sodium hydride; triethylamine; In N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1016/j.ejmech.2013.09.001

upstream raw materials:

2-(1-benzyl-1H-indol-3-yl)-2-oxoacetamide

benzyl bromide

indole

indolyl-3-glyoxylyl chloride