(S)-2-((3-hydroxy-2-methylenebutyl)(4-methoxybenzyl)amino)acetic acid 2,2,2-trifluoroacetic acid salt

Base Information

• Chemical Name: (S)-2-((3-hydroxy-2-methylenebutyl)(4-methoxybenzyl)amino)acetic acid 2,2,2-trifluoroacetic acid salt
• CAS No.: 1450821-30-3
• Molecular Formula: C₂HF₃O₂*C₁₅H₂₁NO₄
• Molecular Weight: 393.36
• Mol file: 1450821-30-3.mol

Synonyms:(S)-2-((3-hydroxy-2-methylenebutyl)(4-methoxybenzyl)amino)acetic acid 2,2,2-trifluoroacetic acid salt

Chemical Property of (S)-2-((3-hydroxy-2-methylenebutyl)(4-methoxybenzyl)amino)acetic acid 2,2,2-trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((3-hydroxy-2-methylenebutyl)(4-methoxybenzyl)amino)acetic acid 2,2,2-trifluoroacetic acid salt

There total 3 articles about (S)-2-((3-hydroxy-2-methylenebutyl)(4-methoxybenzyl)amino)acetic acid 2,2,2-trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(4-Methoxy-benzyl)-amino]-acetic Acid Tert-butyl Ester (98076-56-3) → (S)-2-((3-hydroxy-2-methylenebutyl)(4-methoxybenzyl)amino)acetic acid 2,2,2-trifluoroacetic acid salt (1450821-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

2: dichloromethane / 4 h

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol4019453

Reference yield:

(2S)-3-(bromomethyl)but-3-en-2-ol (736158-13-7) → (S)-2-((3-hydroxy-2-methylenebutyl)(4-methoxybenzyl)amino)acetic acid 2,2,2-trifluoroacetic acid salt (1450821-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

2: dichloromethane / 4 h

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol4019453

Reference yield:

(S)-tert-butyl 2-((3-hydroxy-2-methylenebutyl) (4-methoxybenzyl)amino)acetate (1450821-28-9) + trifluoroacetic acid (76-05-1) → (S)-2-((3-hydroxy-2-methylenebutyl)(4-methoxybenzyl)amino)acetic acid 2,2,2-trifluoroacetic acid salt (1450821-30-3)

Guidance literature:

In dichloromethane; for 4h;

DOI:10.1021/ol4019453

upstream raw materials:

[(4-Methoxy-benzyl)-amino]-acetic Acid Tert-butyl Ester

(S)-tert-butyl 2-((3-hydroxy-2-methylenebutyl) (4-methoxybenzyl)amino)acetate

trifluoroacetic acid

(2S)-3-(bromomethyl)but-3-en-2-ol

Downstream raw materials:

(9aS,E)-8-ethylidene-3-methoxy-1-phenyl-7,8,9,9a-tetrahydro-1H-2-oxa-6a,10adiazabenzo[cd]cyclopenta[g]azulene-6,10-dione

barmumycin

(S)-4-(4-methoxybenzyl)-7-methyl-6-methylene-1,4-oxazepan-2-one

(S,E)-methyl 4-ethylidene-1-(4-hydroxy-3-methoxybenzoyl)pyrrolidine-2-carboxylate