98076-56-3

Upstream product

• 6456-74-2 Glycine tert-butyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 27532-96-3 glycine tert-butyl ester hydrochloride 
• 175708-57-3 [(4-benzyloxy-benzyl)-amino]-acetic acid methyl ester 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 916885-76-2 [(4-methoxybenzyl)(pyridine-3-carbonyl)amino]acetic acid tert-butyl ester 
• 916885-58-0 [(4-methoxybenzyl)(pyridine-4-carbonyl)amino]acetic acid tert-butyl ester 
• 769969-41-7 (2R,5S)-1-benzyl-5-[tert-butoxycarbonylmethyl-(4-methoxybenzyl)carbamoyl]pyrrolidine-2-carboxylic acid ethyl ester 
• 1450821-32-5 (S,E)-methyl 4-ethylidene-1-(4-methoxybenzyl)pyrrolidine-2-carboxylate 
• 1450821-28-9 (S)-tert-butyl 2-((3-hydroxy-2-methylenebutyl) (4-methoxybenzyl)amino)acetate 

Relevant academic research and scientific papers

Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging

Elastic fibers are present in a variety of tissues and are responsible for their resilience. Until now, no optical contrast agent in the near-infrared (NIR) wavelength range of 700–900 nm has been reported for the imaging of elastic fibers. Here, we report the discovery of a NIR zwitterionic elastin probe ElaNIR (elastin NIR) through fluorescent-image-based screening. The probe was successfully applied for in vitro, ex vivo, and in vivo imaging by various imaging modalities. Age-related elastin differences shown by in vivo fluorescent and photoacoustic imaging indicated that ElaNIR can be a potentially convenient tool for uncovering changes of elastin in live models. Technological advancement of microscopic imaging has spurred the development of molecular probes for the detection of biologically and environmentally important analytes. Among fluorescent imaging tools, near-infrared (NIR) fluorescent molecules have been popular for in vivo imaging because of their ability to penetrate tissue deeper with reduced scattering and autofluorescence. Here, we report the discovery of the NIR zwitterionic elastin probe ElaNIR. We found that ElaNIR showed selective binding for elastin, such as those in the aorta, lungs, and skin. ElaNIR also allowed visualization and quantification of elastin levels in young and old mice, which reflect age-dependent changes of elastin in vivo. This makes ElaNIR a unique chemical tool for monitoring changes of elastin in tissue or animal models and provides new opportunities to study the effects of chemical compounds on elastin levels in biological processes. The near-infrared zwitterionic elastin probe ElaNIR for in vivo imaging of elastin structures was found through fluorescent-image-based screening. ElaNIR is well suited for in vitro, ex vivo, and in vivo imaging of elastin and also allows visualization and quantification of elastin levels in young and old mice, which reflect age-dependent changes of elastin in vivo.

Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease

We evaluated the Hepatitis C virus (HCV) NS5B polymerase and HCV NS3/4A protease inhibition activities of a new set of proline-type fullerene derivatives. All of the compounds had the potential to inhibit both the enzymes, indicating that the fullerene derivatives may be dual inhibitors against NS5B and NS3/4A and could be novel lead compounds for the treatment of HCV infections.

Azabicyclic amino acids by stereoselective dearomatizing cyclization of the enolates of N-nicotinoyl glycine derivatives

On activation by pyridine N-acylation, enolates of N-nicotinoyl and N-isonicotinoyl glycine and alanine derivatives cyclize to yield 6,5-azabicyclic or 6,4-azaspirocyclic lactams. With an N-α-methyl-p-methoxybenzyl group the cyclization is diastereoselect

CONJUGATES OF 2,4-ETHANO-BRIDGED AND 2,4-PROPANO-BRIDGED 3,6,9-TRIAZA-NONANOIC ACID, 3N,6N,9,9N-TETRAETHANOIC ACID, AND CORRESPONDING PHOSPHORIC ACID METHYLENE DERIVATIVES AND THE SUBSTITUTION PRODUCTS THEREOF WITH BIOMOLECULES, METHODS FOR THE PRODUCTION THEREOF, AND THE USE OF THE SAME FOR PRODU

The invention relates to conjugates of 2,4-ethano-bridged and 2,4-propano-bridged 3,6,9-triaza-nonanoic acid, N,N,N-tetraethanoic acid, and corresponding phosphoric acid ester methylene derivatives of formula (1) - wherein the substituents are defined as cited in patent claim 1 - and the substitution products thereof with biomolecules. The invention also relates to methods for producing said conjugates and to the use of the same as contrasting media in NMR diagnosis and radiodiagnosis, and for radiotherapy.

Cycloalkyl inhibitors of protein farnesyltransferase

Novel inhibitors of protein farnesyltransferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer, restenosis, atheros