N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide

Base Information

Chemical Name:N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide
CAS No.:1592908-83-2
Molecular Formula:C₃₉H₄₁BrFN₃O₇
Molecular Weight:762.673
Hs Code.:

N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide

Synonyms:N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide

Suppliers and Price of N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide

There total 8 articles about N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1592908-76-3
C₃₂H₃₇BrFN₃O₆

: 98-88-4
benzoyl chloride

: 1592908-83-2
N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201301769

Reference yield:

: 1016896-54-0
(2S,3S)-ethyl-3-(allyloxycarbonylamino)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-carboxylate

: 1592908-83-2
N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate; diphenylphosphoranyl azide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3: triphenylphosphine / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere

4: sodium cyanoborohydride; acetic acid / ethanol / 4 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; PyBroP / dichloromethane / 20 °C / Inert atmosphere

6: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 0 °C / Inert atmosphere; Darkness

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With morpholine; lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; PyBroP; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/ejoc.201301769

Reference yield:

: allyl (2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylcarbamate

: 1592908-83-2
N-((S)-1-((((2R,3S)-3-benzamido-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-3-methyl-1-oxobutan-2-yl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; diethylazodicarboxylate; diphenylphosphoranyl azide / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere

3: sodium cyanoborohydride; acetic acid / ethanol / 4 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; PyBroP / dichloromethane / 20 °C / Inert atmosphere

5: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 1 h / 0 °C / Inert atmosphere; Darkness

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; PyBroP; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/ejoc.201301769