2,6-Dichloro-α-(4-chlorophenyl)-4-nitrobenzeneacetonitrile

Base Information

• Chemical Name: 2,6-Dichloro-α-(4-chlorophenyl)-4-nitrobenzeneacetonitrile
• CAS No.: 103317-59-5
• Molecular Formula: C₁₄H₇Cl₃N₂O₂
• Molecular Weight: 341.581
• Mol file: 103317-59-5.mol

Synonyms:2-(4'-chlorophenyl)-2-(2,6-dichloro-4-nitrophenyl)acetonitrile

Chemical Property of 2,6-Dichloro-α-(4-chlorophenyl)-4-nitrobenzeneacetonitrile

Chemical Property:

• Melting Point: 106 - 112oC
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

2,?6-?Dichloro-?α-?(4-?chlorophenyl)?-?4-?nitrobenzeneacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2,6-Dichloro-α-(4-chlorophenyl)-4-nitrobenzeneacetonitrile is used in the synthesis of anticoccidial triazine compounds.

Technology Process of 2,6-Dichloro-α-(4-chlorophenyl)-4-nitrobenzeneacetonitrile

There total 3 articles about 2,6-Dichloro-α-(4-chlorophenyl)-4-nitrobenzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,4,5-trichloronitrobenzen (20098-48-0) + p-chlorobenzyl cyanide (140-53-4) → 2-(4'-chlorophenyl)-2-(2,6-dichloro-4-nitrophenyl)acetonitrile (103317-59-5)

Guidance literature:

3,4,5-trichloronitrobenzen; With tetrabutylammomium bromide; sodium hydroxide; In water; for 0.5h;

p-chlorobenzyl cyanide; In tetrahydrofuran; water; at 60 ℃; for 8h;

Reference yield:

3,4,5-trichloronitrobenzen (20098-48-0) + N-benzyl-N,N,N-triethylammonium chloride (56-37-1) + p-chlorobenzyl cyanide (140-53-4) → 2-(4'-chlorophenyl)-2-(2,6-dichloro-4-nitrophenyl)acetonitrile (103317-59-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; di-isopropyl ether;

Reference yield:

4-nitro-2,6-dichloroaniline (99-30-9) → 2-(4'-chlorophenyl)-2-(2,6-dichloro-4-nitrophenyl)acetonitrile (103317-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; sodium nitrite / 0.33 h / 5 - 70 °C

1.2: 0.5 h

1.3: 1 h / 25 - 70 °C

2.1: sodium hydroxide / butanone / 2 h / 50 °C

With sulfuric acid; sodium hydroxide; sodium nitrite; In butanone;

upstream raw materials:

3,4,5-trichloronitrobenzen

N-benzyl-N,N,N-triethylammonium chloride

p-chlorobenzyl cyanide

4-nitro-2,6-dichloroaniline

Downstream raw materials:

diclazuril

2,6-dichloro-alpha-(4-chlorophenyl)-4-aminobenzeneacetonitrile

Refernces

• 1、 -. "A coccidian preparation method". . . Retrieved 2018/09/02.