4-AMino-2,6-dichloro-α-(4-chlorophenyl)benzeneacetonitrile

Base Information

• Chemical Name: 4-AMino-2,6-dichloro-α-(4-chlorophenyl)benzeneacetonitrile
• CAS No.: 132252-58-5
• Molecular Formula: C₁₄H₉Cl₃N₂
• Molecular Weight: 311.598
• Hs Code.: 2926907090
• Mol file: 132252-58-5.mol

Synonyms:4-AMino-2,6-dichloro-α-(4-chlorophenyl)benzeneacetonitrile

Chemical Property of 4-AMino-2,6-dichloro-α-(4-chlorophenyl)benzeneacetonitrile

Chemical Property:

• PSA: 49.81000
• LogP: 5.46568

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-2,6-dichloro-α-(4-chlorophenyl)benzeneacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-AMino-2,6-dichloro-α-(4-chlorophenyl)benzeneacetonitrile is used in the synthesis of Diclazuril (D436200) and diclazuril derivatives.

Technology Process of 4-AMino-2,6-dichloro-α-(4-chlorophenyl)benzeneacetonitrile

There total 4 articles about 4-AMino-2,6-dichloro-α-(4-chlorophenyl)benzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

2-(4'-chlorophenyl)-2-(2,6-dichloro-4-nitrophenyl)acetonitrile (103317-59-5) → 2,6-dichloro-alpha-(4-chlorophenyl)-4-aminobenzeneacetonitrile (132252-58-5)

Guidance literature:

With iron(III) chloride; pyrographite; hydrazine hydrate; In Isopropyl acetate; at 75 ℃; for 4h; Temperature; Solvent;

Reference yield:

3,4,5-trichloronitrobenzen (20098-48-0) + p-chlorobenzyl cyanide (140-53-4) → 2,6-dichloro-alpha-(4-chlorophenyl)-4-aminobenzeneacetonitrile (132252-58-5)

Guidance literature:

3,4,5-trichloronitrobenzen; With tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; water; at 40 ℃; for 0.5h;

p-chlorobenzyl cyanide; In tetrahydrofuran; water; at 60 ℃; for 8h;

With sodium dithionite; In tetrahydrofuran; water; for 6h; Reflux;

Reference yield:

4-nitro-2,6-dichloroaniline (99-30-9) → 2,6-dichloro-alpha-(4-chlorophenyl)-4-aminobenzeneacetonitrile (132252-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; sodium nitrite / 0.67 h / 50 °C

1.2: 1 h / 5 °C

1.3: 1.83 h / 15 - 70 °C

2.1: sodium hydroxide; tetrabutylammomium bromide / water; tetrahydrofuran / 0.5 h / 40 °C

2.2: 8 h / 60 °C

2.3: 6 h / Reflux

With sulfuric acid; tetrabutylammomium bromide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; water; 1.1: |Sandmeyer Reaction / 1.2: |Sandmeyer Reaction / 1.3: |Sandmeyer Reaction;

upstream raw materials:

3,4,5-trichloronitrobenzen

p-chlorobenzyl cyanide

4-nitro-2,6-dichloroaniline

2-(4'-chlorophenyl)-2-(2,6-dichloro-4-nitrophenyl)acetonitrile

Downstream raw materials:

diclazuril

Refernces

• 1、 -. "A coccidian preparation method". . . Retrieved 2018/09/02.