(-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane

Base Information

Chemical Name:(-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane
CAS No.:165960-90-7
Molecular Formula:C₂₉H₃₂N₂O₁₂
Molecular Weight:600.579
Hs Code.:

Synonyms:(-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane

Suppliers and Price of (-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane

There total 1 articles about (-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: [(2S,3S)-3-(2-{(4R,5R)-5-[2-((2S,3S)-3-Hydroxymethyl-oxiranyl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl)-oxiranyl]-methanol

: 165960-90-7
(-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane

Guidance literature:: With triethylamine; In dichloromethane; toluene; at 0 ℃; for 1h; Yield given;
DOI:10.1021/jo00119a019

Reference yield: 92.0%

: 165960-90-7
(-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane

: 204637-90-1
(-)-(2S,3R,6R,7R,10R,11S)-1,12-O-Bis(4-nitrobenzoyl)-3,6:7,10-diepoxy-1,2,11,12-tetrahydroxydodecane

Guidance literature:: With boron trifluoride diethyl etherate; water; In methanol; dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jo00119a019

Reference yield:

: 165960-90-7
(-)-(2S,3S,6R,7R,10S,11S)-2,3:10,11-Diepoxy-6,7-O-isopropylidene-1,12-O-bis(4-nitrobenzoyl)-1,6,7,12-tetrahydroxydodecane

: 165961-06-8
Toluene-4-sulfonic acid (S)-2-{(2R,5R,2'R,5'R)-5'-[(1R,12R)-15-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-12-methoxymethoxy-pentadecyl]-octahydro-[2,2']bifuranyl-5-yl}-2-hydroxy-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / BF₃*Et₂O, H₂O / methanol; CH₂Cl₂ / 5 h / Ambient temperature

2: 37 percent / Et₃N / tetrahydrofuran / 0 °C

3: n-Bu₄NOH / methanol; tetrahydrofuran / 1 h / Ambient temperature

4: 83 percent / n-BuLi / hexane; 1,2-dimethoxy-ethane / 0.17 h / Ambient temperature

5: 60 percent / sodium amalgam / ethanol / 24 h / Ambient temperature

6: 42 percent / pyridine / 48 h / -20 °C

With pyridine; sodium amalgam; n-butyllithium; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydroxide; water; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane;
DOI:10.1021/jo00119a019