[2-(1-Benzyl-5-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester

Base Information

Chemical Name:[2-(1-Benzyl-5-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester
CAS No.:193604-39-6
Molecular Formula:C₂₁H₂₄N₂O₄
Molecular Weight:368.433
Hs Code.:

Synonyms:[2-(1-Benzyl-5-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester

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Chemical Property of [2-(1-Benzyl-5-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester

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Technology Process of [2-(1-Benzyl-5-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester

There total 4 articles about [2-(1-Benzyl-5-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

: 193604-38-5
[2-(1-Benzyl-5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester

: 74-88-4
methyl iodide

: 193604-39-6
[2-(1-Benzyl-5-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester

Guidance literature:: With sodium hydroxide; trimethylbenzylammonium bromide; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm970210v

Reference yield:

: 608-07-1
2-(5-methoxyindol-3-yl)ethylamine

: 193604-39-6
[2-(1-Benzyl-5-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 0.33 h / Ambient temperature

2: 1.) NaH / 1.) DMSO, RT, 20 min, 2.) DMSO, 2 h

3: 77.5 percent / DMSO, 36percent aq. HCl / 1 h / Ambient temperature

4: 94.9 percent / 20percent aq. NaOH, benzyltrimethylammonium bromide / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; trimethylbenzylammonium bromide; sodium hydride; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1021/jm970210v

Reference yield:

: 67199-10-4
methyl N-[2-(5-methoxy-1H-indol-3-yl)ethyl]carbamate

: 193604-39-6
[2-(1-Benzyl-5-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMSO, RT, 20 min, 2.) DMSO, 2 h

2: 77.5 percent / DMSO, 36percent aq. HCl / 1 h / Ambient temperature

3: 94.9 percent / 20percent aq. NaOH, benzyltrimethylammonium bromide / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; trimethylbenzylammonium bromide; sodium hydride; dimethyl sulfoxide; In dichloromethane;
DOI:10.1021/jm970210v