2-thioxo-1,2,5,6,7,8,9,10,11,12-decahydrocyclodeca[b]pyridine-3-carbonitrile

Base Information

• Chemical Name: 2-thioxo-1,2,5,6,7,8,9,10,11,12-decahydrocyclodeca[b]pyridine-3-carbonitrile
• CAS No.: 154384-03-9
• Molecular Formula: C₁₄H₁₈N₂S
• Molecular Weight: 246.376

Synonyms:2-thioxo-1,2,5,6,7,8,9,10,11,12-decahydrocyclodeca[b]pyridine-3-carbonitrile

Chemical Property of 2-thioxo-1,2,5,6,7,8,9,10,11,12-decahydrocyclodeca[b]pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 2-thioxo-1,2,5,6,7,8,9,10,11,12-decahydrocyclodeca[b]pyridine-3-carbonitrile

There total 2 articles about 2-thioxo-1,2,5,6,7,8,9,10,11,12-decahydrocyclodeca[b]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Cyanothioacetamide (7357-70-2) + Sodium; [2-oxo-cyclodec-(Z)-ylidene]-methanolate → 2-thioxo-1,2,5,6,7,8,9,10,11,12-decahydrocyclodeca[b]pyridine-3-carbonitrile (154384-03-9)

Guidance literature:

With piperdinium acetate; In water; for 0.166667h; Heating;

DOI:10.1016/S0040-4020(01)80745-6

Reference yield:

Cyanothioacetamide (7357-70-2) + C11H17O2(1-)*Na(1+) → 2-thioxo-1,2,5,6,7,8,9,10,11,12-decahydrocyclodeca[b]pyridine-3-carbonitrile (154384-03-9)

Guidance literature:

Cyanothioacetamide; C₁₁H₁₇O₂^(1-)*Na⁽¹⁺⁾; With piperdinium acetate; In water; at 20 ℃; for 48h; Reflux; Inert atmosphere;

With acetic acid; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.12.009

Reference yield: 52.0%

2-bromo-N-(2'-chlorophenyl)acetamide (5439-11-2) + 2-thioxo-1,2,5,6,7,8,9,10,11,12-decahydrocyclodeca[b]pyridine-3-carbonitrile (154384-03-9) → 3-amino-N-(2'-chlorophenyl)-5,6,7,8,9,10,11,12-octahydrocyclodeca[b]thieno[3,2-e]pyridine-2-carboxamide

Guidance literature:

With sodium carbonate; In ethanol; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.12.009

upstream raw materials:

Cyanothioacetamide

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