(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid

Base Information

Chemical Name:(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid
CAS No.:97280-34-7
Molecular Formula:C₂₄H₂₇N₅O₆
Molecular Weight:481.508
Hs Code.:

Synonyms:(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid

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Chemical Property of (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid

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Technology Process of (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid

There total 4 articles about (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 97280-26-7
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

: 97280-34-7
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 2h; Ambient temperature;
DOI:10.1021/jm00148a016

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 97280-34-7
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / dimethylformamide / 21 h / 110 °C

2: 33 percent / CaCO₃ / N,N-dimethyl-acetamide / 93 h / 25 °C

3: 78 percent / aq. NaOH / ethanol / 2 h / Ambient temperature

With sodium hydroxide; calcium carbonate; In ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00148a016

Reference yield:

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 97280-34-7
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 33 percent / CaCO₃ / N,N-dimethyl-acetamide / 93 h / 25 °C

2: 78 percent / aq. NaOH / ethanol / 2 h / Ambient temperature

With sodium hydroxide; calcium carbonate; In ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00148a016