(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

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Chemical Name:(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid diethyl ester
CAS No.:97280-26-7
Molecular Formula:C₂₈H₃₅N₅O₆
Molecular Weight:537.616
Hs Code.:

Synonyms:(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

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Technology Process of (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

There total 2 articles about (S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 97280-19-8
diethyl N-<4-(prop-2-ylamino)benzoyl>-L-glutamate

: 97280-26-7
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: With calcium carbonate; In N,N-dimethyl acetamide; at 25 ℃; for 93h;
DOI:10.1021/jm00148a016

Reference yield:

: 13726-52-8
diethyl N-(p-aminobenzoyl)-L-glutamate

: 97280-26-7
(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-isopropyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / dimethylformamide / 21 h / 110 °C

2: 33 percent / CaCO₃ / N,N-dimethyl-acetamide / 93 h / 25 °C

With calcium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00148a016