3-(5-amino-4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-pyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

Base Information

Chemical Name:3-(5-amino-4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-pyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile
CAS No.:1018979-06-0
Molecular Formula:C₃₈H₃₇N₇OSi
Molecular Weight:635.844
Hs Code.:

Synonyms:3-(5-amino-4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-pyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

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Chemical Property of 3-(5-amino-4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-pyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

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Technology Process of 3-(5-amino-4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-pyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

There total 9 articles about 3-(5-amino-4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-pyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083302-64-0
3-(4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-5-nitropyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

: 1018979-06-0
3-(5-amino-4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-pyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: With hydrogen; 5percentPt/C (sulfided); In methanol; ethyl acetate; at 20 ℃; for 15h; under 2068.65 Torr;

Reference yield:

: 1019207-94-3
(R)-2,2,2-trifluoro-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamide

: 1018979-06-0
3-(5-amino-4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-pyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium sulfate / water; acetone / 0.08 h / 0 °C

1.2: 0 - 20 °C

2.1: formic acid; triethylamine / Noyori's catalyst / N,N-dimethyl-formamide / 50 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: potassium carbonate / methanol; water / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

6.1: hydrogen / 5percentPt/C (sulfided) / methanol; ethyl acetate / 15 h / 20 °C / 2068.65 Torr

With 1H-imidazole; formic acid; hydrogen; magnesium sulfate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; Noyori's catalyst; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1018978-46-5
2,2,2-trifluoro-N-[(1R)-4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl]acetamide

: 1018979-06-0
3-(5-amino-4-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-ylamino)-pyrimidin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: formic acid; triethylamine / Noyori's catalyst / N,N-dimethyl-formamide / 50 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / methanol; water / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

5: hydrogen / 5percentPt/C (sulfided) / methanol; ethyl acetate / 15 h / 20 °C / 2068.65 Torr

With 1H-imidazole; formic acid; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; Noyori's catalyst; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;