3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

Base Information

Chemical Name:3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile
CAS No.:1141855-93-7
Molecular Formula:C₄₀H₃₇N₇O₂Si
Molecular Weight:675.865
Hs Code.:

3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

Synonyms:3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

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Chemical Property of 3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

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Technology Process of 3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

There total 11 articles about 3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083302-69-5
3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

: 74-88-4
methyl iodide

: 1141855-93-7
3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene; In acetonitrile; at 20 ℃; for 15h; Polystyrene

Reference yield:

: 1019207-94-3
(R)-2,2,2-trifluoro-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamide

: 1141855-93-7
3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium sulfate / water; acetone / 0.08 h / 0 °C

1.2: 0 - 20 °C

2.1: formic acid; triethylamine / Noyori's catalyst / N,N-dimethyl-formamide / 50 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: potassium carbonate / methanol; water / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

6.1: hydrogen / 5percentPt/C (sulfided) / methanol; ethyl acetate / 15 h / 20 °C / 2068.65 Torr

7.1: tetrahydrofuran / 15 h

8.1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene / acetonitrile / 15 h / 20 °C

With 1H-imidazole; formic acid; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene; hydrogen; magnesium sulfate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; Noyori's catalyst; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 1018978-46-5
2,2,2-trifluoro-N-[(1R)-4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl]acetamide

: 1141855-93-7
3-(9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: formic acid; triethylamine / Noyori's catalyst / N,N-dimethyl-formamide / 50 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: potassium carbonate / methanol; water / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

5: hydrogen / 5percentPt/C (sulfided) / methanol; ethyl acetate / 15 h / 20 °C / 2068.65 Torr

6: tetrahydrofuran / 15 h

7: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene / acetonitrile / 15 h / 20 °C

With 1H-imidazole; formic acid; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; Noyori's catalyst; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;