3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan

Base Information

Chemical Name:3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan
CAS No.:78310-35-7
Molecular Formula:C₂₄H₃₆O₄
Molecular Weight:388.547
Hs Code.:

Synonyms:3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan

Suppliers and Price of 3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan

There total 17 articles about 3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 78310-34-6,78310-38-0
(1R,2R,4aS,8aS)-1-[(2,6-Dimethoxy-4-methyl-phenyl)-hydroxy-methyl]-8a-methoxymethyl-2,5,5-trimethyl-decahydro-naphthalen-2-ol

: 78310-35-7
3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan

Guidance literature:: With pyridine hydrochloride; In dichloromethane; at 25 ℃; for 0.5h;
DOI:10.1021/ja00399a062

Reference yield: 78.0%

: 78310-34-6,78310-38-0
(2,6-dimethoxy-4-methyl)phenyl-1-(8aα-methoxymethyl-2α-hydroxy-2β,5,5-trimethyl-1,2,3,4,4aα,5,6,7,8,8a-decahydronaphthyl)methanol

: 78310-35-7
3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan

Guidance literature:: With pyridine hydrochloride; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90005-5

Reference yield:

: 78412-85-8,135163-81-4
8aα-methoxymethyl-5,5-dimethyl-4aα,5,6,7,8,8a-hexahydro-2(1H)-naphthalenone

: 78310-35-7
3β,6,6-trimethyl-3α-hydroxy-2β-(2,6-dimethoxy-4-methyl)phenyl-2α,2aβ,3,4,5,5aα,6,7,8,9,9a,-10-dodecahydronaphtho<1,8a-c>furan

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) (i-Pr)2NLi / 1.) DME, -78 deg C

2: 100 percent / H₂ / Pd-C / ethanol

3: 89 percent / pyridinium tosylate / CH₂Cl₂

4: 99 percent / diethyl ether

5: 90 percent / PPTS, aq.EtOH / 60 °C

6: 80 percent / PCC / CH₂Cl₂

7: 1.) Li / 2.) DME, -75 -> 0 deg C

8: 78 percent / pyridinium chloride / CH₂Cl₂ / 0.5 h / 25 °C

With ethanol; hydrogen; pyridine hydrochloride; pyridinium p-toluenesulfonate; lithium; pyridinium chlorochromate; lithium diisopropyl amide; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ja00399a062