Technology Process of 4,5-dimethoxy-1-phenyl-8-thia-9-azatricyclo[7.2.1.02,7]dodeca-2(7),3,5,10-tetraene-8,8-dioxide
There total 6 articles about 4,5-dimethoxy-1-phenyl-8-thia-9-azatricyclo[7.2.1.02,7]dodeca-2(7),3,5,10-tetraene-8,8-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium diacetate; potassium carbonate; triphenylphosphine;
In
N,N-dimethyl-formamide;
at 110 ℃;
for 18h;
Reagent/catalyst;
regioselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201201359
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
1.2: 17 h / 0 - 20 °C
2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 15 h / 40 °C / Inert atmosphere
3.1: triphenylphosphine; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere
With
Hoveyda-Grubbs catalyst second generation; palladium diacetate; sodium hydride; potassium carbonate; triphenylphosphine;
In
dichloromethane; N,N-dimethyl-formamide; mineral oil;
3.1: |Heck Reaction;
DOI:10.1002/chem.201201359
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 15 h / 40 °C / Inert atmosphere
2: triphenylphosphine; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere
With
Hoveyda-Grubbs catalyst second generation; palladium diacetate; potassium carbonate; triphenylphosphine;
In
dichloromethane; N,N-dimethyl-formamide;
2: |Heck Reaction;
DOI:10.1002/chem.201201359
