1-(2-bromo-4,5-dimethoxyphenylsulfonyl)-3-phenyl-2,5-dihydro-1H-pyrrole

Base Information

• Chemical Name: 1-(2-bromo-4,5-dimethoxyphenylsulfonyl)-3-phenyl-2,5-dihydro-1H-pyrrole
• CAS No.: 1421639-48-6
• Molecular Formula: C₁₈H₁₈BrNO₄S
• Molecular Weight: 424.315

Synonyms:1-(2-bromo-4,5-dimethoxyphenylsulfonyl)-3-phenyl-2,5-dihydro-1H-pyrrole

Chemical Property of 1-(2-bromo-4,5-dimethoxyphenylsulfonyl)-3-phenyl-2,5-dihydro-1H-pyrrole

Chemical Property:

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Technology Process of 1-(2-bromo-4,5-dimethoxyphenylsulfonyl)-3-phenyl-2,5-dihydro-1H-pyrrole

There total 5 articles about 1-(2-bromo-4,5-dimethoxyphenylsulfonyl)-3-phenyl-2,5-dihydro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-allyl-N-2-phenylallyl-(2-bromobenzene)sulfonamide (1421639-43-1) → 1-(2-bromo-4,5-dimethoxyphenylsulfonyl)-3-phenyl-2,5-dihydro-1H-pyrrole (1421639-48-6)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 40 ℃; for 15h; Inert atmosphere;

DOI:10.1002/chem.201201359

Reference yield:

N-allyl-2-bromo-4,5-dimethoxybenzenesulfonamide (1378317-35-1) → 1-(2-bromo-4,5-dimethoxyphenylsulfonyl)-3-phenyl-2,5-dihydro-1H-pyrrole (1421639-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 17 h / 0 - 20 °C

2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 15 h / 40 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/chem.201201359

Reference yield:

2-bromo-4,5-dimethoxybenzene-1-sulfonyl chloride (51072-64-1) → 1-(2-bromo-4,5-dimethoxyphenylsulfonyl)-3-phenyl-2,5-dihydro-1H-pyrrole (1421639-48-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 17 h / 0 - 20 °C

3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 15 h / 40 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/chem.201201359

upstream raw materials:

N-allyl-2-bromo-4,5-dimethoxybenzenesulfonamide

3-bromo-2-phenylprop-1-ene

isopropenylbenzene

N-allyl-N-2-phenylallyl-(2-bromobenzene)sulfonamide

Downstream raw materials:

4,5-dimethoxy-1-phenyl-8-thia-9-azatricyclo[7.2.1.0^2,7]dodeca-2⁽⁷⁾,3,5,10-tetraene-8,8-dioxide

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