(R)-N-(4-(1-aminoethyl)-2,6-difluoro-phenyl)-methanesulfonamide hydrochloride

Base Information

Chemical Name:(R)-N-(4-(1-aminoethyl)-2,6-difluoro-phenyl)-methanesulfonamide hydrochloride
CAS No.:956901-23-8
Molecular Formula:C₉H₁₂F₂N₂O₂S*ClH
Molecular Weight:286.73
Hs Code.:2935909099
Mol file:956901-23-8.mol

Synonyms:N-{4-[(1R)-1-aminoethyl]-2,6-difluorophenyl}methanesulfonamide hydrochloride

Suppliers and Price of (R)-N-(4-(1-aminoethyl)-2,6-difluoro-phenyl)-methanesulfonamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of (R)-N-(4-(1-aminoethyl)-2,6-difluoro-phenyl)-methanesulfonamide hydrochloride

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-N-(4-(1-aminoethyl)-2,6-difluoro-phenyl)-methanesulfonamide hydrochloride

There total 7 articles about (R)-N-(4-(1-aminoethyl)-2,6-difluoro-phenyl)-methanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 956901-22-7
N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]methanesulfonamide

: 956901-23-8
N-{4-[(1R)-1-aminoethyl]-2,6-difluorophenyl}methanesulfonamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 24h;

Reference yield:

: (R)-N-{2,6-difluoro-4-[1-(2-methylpropane-2-sulfinylamino)ethyl]phenyl}methanesulfonamide

: 956901-23-8
N-{4-[(1R)-1-aminoethyl]-2,6-difluorophenyl}methanesulfonamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;

Reference yield:

: 67567-26-4
4-bromo-2,6-difluoroaniline

: 956901-23-8
N-{4-[(1R)-1-aminoethyl]-2,6-difluorophenyl}methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 6 h / 20 - 50 °C

2.1: potassium carbonate / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide; water / 0.5 h / 100 °C / Microwave irradiation

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 18 h / 70 °C / Inert atmosphere

4.1: sodium tetrahydroborate / tetrahydrofuran / 5 h / -70 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane; methanol / 24 h / 20 °C

With pyridine; hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; potassium carbonate; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;