2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide

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Chemical Name:2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide
CAS No.:956901-20-5
Molecular Formula:C₂₃H₂₉F₂N₃O₃S
Molecular Weight:465.564
Hs Code.:

Synonyms:2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide

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Chemical Property of 2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide

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Technology Process of 2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide

There total 5 articles about 2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 2-(6-tert-butylpyridin-3-yl)-2-methylcyclopropanecarboxylic acid

: 956901-23-8
N-{4-[(1R)-1-aminoethyl]-2,6-difluorophenyl}methanesulfonamide hydrochloride

: 956901-20-5
2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 67567-26-4
4-bromo-2,6-difluoroaniline

: 956901-20-5
2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 6 h / 20 - 50 °C

2.1: potassium carbonate / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / water; N,N-dimethyl-formamide / 0.5 h / 100 °C / microwave irradiation

2.2: 14 h / 20 °C

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 18 h / 70 °C

3.2: 16 h / -20 - 20 °C

4.1: hydrogenchloride; methanol / 24 h / 20 °C

5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 1 h / 20 °C

With pyridine; hydrogenchloride; methanol; titanium(IV) tetraethanolate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 886842-80-4
N-(4-bromo-2,6-difluorophenyl)methanesulfonamide

: 956901-20-5
2-(6-tert-butylpyridin-3-yl)-N-((1R)-1-{3,5-difluoro-4-[(methylsulfonyl)amino]phenyl}ethyl)-2-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / water; N,N-dimethyl-formamide / 0.5 h / 100 °C / microwave irradiation

1.2: 14 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 18 h / 70 °C

2.2: 16 h / -20 - 20 °C

3.1: hydrogenchloride; methanol / 24 h / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 1 h / 20 °C

With hydrogenchloride; methanol; titanium(IV) tetraethanolate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;