5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

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Chemical Name:5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide
CAS No.:1450598-94-3
Molecular Formula:C₂₉H₃₁ClFN₅O₅S
Molecular Weight:616.113
Hs Code.:

Synonyms:5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

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Chemical Property of 5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

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Technology Process of 5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

There total 7 articles about 5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1354787-43-1
5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2,4-difluoro-N-(pyrimidin-4-yl)benzene-1-sulfonamide

: 1450595-87-5
(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexan-1-ol

: 1450598-94-3
5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Guidance literature:: With sodium hydride; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c00259

Reference yield: 50.0%

: 1450598-94-3
5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Guidance literature:: With sodium hydride; In water; N,N-dimethyl-formamide; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 1450598-94-3
5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: 20 h / -78 °C

2.1: ethanol; hexane / Resolution of racemate

3.1: sodium hydride / 1 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/acs.jmedchem.0c00259