5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Base Information

Chemical Name:5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide
CAS No.:1450595-86-4
Molecular Formula:C₂₀H₂₁ClFN₅O₃S
Molecular Weight:465.936
Hs Code.:

Synonyms:5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Suppliers and Price of 5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

There total 4 articles about 5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1450598-94-3
5-chloro-N-[(2,4-dimethoxyphenyl)methyl]-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

: 1450595-86-4
5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 1450595-86-4
5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: 20 h / -78 °C

2.1: ethanol; hexane / Resolution of racemate

3.1: sodium hydride / 1 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; triethylsilane / dichloromethane / 1 h / 20 °C

With triethylsilane; n-butyllithium; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/acs.jmedchem.0c00259

Reference yield:

: (1S*,2R*)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexan-1-ol

: 1450595-86-4
5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; hexane / Resolution of racemate

2: sodium hydride / 1 h / 0 - 20 °C / Inert atmosphere

3: trifluoroacetic acid; triethylsilane / dichloromethane / 1 h / 20 °C

With triethylsilane; sodium hydride; trifluoroacetic acid; In ethanol; hexane; dichloromethane;
DOI:10.1021/acs.jmedchem.0c00259