N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester
• CAS No.: 908341-13-9
• Molecular Formula: C₁₅H₂₁N₃O₅
• Molecular Weight: 323.349
• Mol file: 908341-13-9.mol

Synonyms:N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester

Chemical Property of N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester

There total 1 articles about N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic anhydride (108-24-7) + N'-(5-amino-2-methoxy-benzoyl)-hydrazinecarboxylic acid tert-butyl ester (295800-35-0) → N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester (908341-13-9)

Guidance literature:

In tetrahydrofuran;

DOI:10.1002/ejoc.201700010

Reference yield:

N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester (908341-13-9) → N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide (131308-91-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jm060576k

Reference yield:

N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester (908341-13-9) → N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide (908341-15-1)

Guidance literature:

Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂ / 3 h / 20 °C

2: 201 mg / DIPEA; O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium*PF₆; 1-hydroxybenzotriazole / dimethylformamide / 24 h / 20 °C

3: H₂ / Pd/C / dimethylformamide / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm060576k

upstream raw materials:

acetic anhydride

N'-(5-amino-2-methoxy-benzoyl)-hydrazinecarboxylic acid tert-butyl ester

Downstream raw materials:

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide

N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide

{1-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazinocarbonyl]-2-methylpropyl}carbamic acid benzyl ester