N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide

Base Information

• Chemical Name: N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide
• CAS No.: 908341-15-1
• Molecular Formula: C₁₅H₂₂N₄O₄
• Molecular Weight: 322.364
• Mol file: 908341-15-1.mol

Synonyms:N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide

Chemical Property of N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide

There total 4 articles about N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{1-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazinocarbonyl]-2-methylpropyl}carbamic acid benzyl ester (908341-14-0) → N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide (908341-15-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jm060576k

Reference yield:

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide (131308-91-3) → N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide (908341-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 201 mg / DIPEA; O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium*PF₆; 1-hydroxybenzotriazole / dimethylformamide / 24 h / 20 °C

2: H₂ / Pd/C / dimethylformamide / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1021/jm060576k

Reference yield:

N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester (908341-13-9) → N-[3-[[[(2S)-2-amino-3-methylbutanoyl]amino]carbamoyl]-4-methoxyphenyl]acetamide (908341-15-1)

Guidance literature:

Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂ / 3 h / 20 °C

2: 201 mg / DIPEA; O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium*PF₆; 1-hydroxybenzotriazole / dimethylformamide / 24 h / 20 °C

3: H₂ / Pd/C / dimethylformamide / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm060576k

upstream raw materials:

{1-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazinocarbonyl]-2-methylpropyl}carbamic acid benzyl ester

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide

N'-(5-acetylamino-2-methoxybenzoyl)hydrazinecarboxylic acid tert-butyl ester

N'-(5-amino-2-methoxy-benzoyl)-hydrazinecarboxylic acid tert-butyl ester

Downstream raw materials:

C₅₄H₇₁N₉O₁₄

C₅₁H₆₇N₉O₁₄

C₄₈H₆₁N₉O₁₂

C₄₈H₆₀N₈O₁₂