(E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate

Base Information

Chemical Name:(E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate
CAS No.:1361060-70-9
Molecular Formula:C₂₂H₂₅NO₃
Molecular Weight:351.445
Hs Code.:

Synonyms:(E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate

Suppliers and Price of (E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate

There total 4 articles about (E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1007389-67-4
C₁₅H₁₉NO₂

: 100-52-7
benzaldehyde

: 1361060-70-9
(E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate

Guidance literature:: With nickel(II)-2,2'-bipyridine bromide; tetrabutylammonium tetrafluoroborate; In N,N-dimethyl-formamide; at 50 ℃; for 2.25h; Inert atmosphere; Electrolysis;
DOI:10.1021/acs.joc.1c00811

Reference yield: 64.0%

: 1361060-55-0
tert-butyl but-2-ynyl(2-iodophenyl)carbamate

: 100-52-7
benzaldehyde

: 1361060-70-9
(E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate

Guidance literature:: With manganese; bis(bipyridine)nickel(II) bromide; trifluoroacetic acid; In N,N-dimethyl-formamide; at 50 ℃; for 2h; stereoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201100967

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 1361060-70-9
(E)-tert-butyl 3-(1-hydroxy-1-phenylpropan-2-ylidene)-indoline-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 70 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.92 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: manganese; bis(bipyridine)nickel(II) bromide; trifluoroacetic acid / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

With manganese; bis(bipyridine)nickel(II) bromide; diphenyl phosphoryl azide; sodium hydride; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide; toluene; 1.1: Curtius rearrangement;
DOI:10.1002/chem.201100967