(R)-3-{(2S,3R,5S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionic acid methyl ester

Base Information

Chemical Name:(R)-3-{(2S,3R,5S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionic acid methyl ester
CAS No.:83061-06-7
Molecular Formula:C₂₉H₄₂O₅Si
Molecular Weight:498.735
Hs Code.:

Synonyms:(R)-3-{(2S,3R,5S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionic acid methyl ester

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Chemical Property of (R)-3-{(2S,3R,5S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionic acid methyl ester

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Technology Process of (R)-3-{(2S,3R,5S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionic acid methyl ester

There total 5 articles about (R)-3-{(2S,3R,5S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83061-03-4
(1S,2S,3R)-3-(2-Benzyloxy-ethyl)-2-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-cyclopentanol

: 83061-06-7
(R)-3-{(2S,3R,5S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) CrO₃*2Py, 2.) MCPBA, NaHCO₃, <(Me)3CC₆H₂(Me)OH>2S / 1.) CH₂Cl₂, 0 deg C (10 min) -> 25 deg C (30 min), 2.) 0 deg C

2: LDA / tetrahydrofuran / -78 deg C -> -40 deg C

3: hydrogen / Pd-C / ethanol

4: CrO₃*2Py / CH₂Cl₂

5: TsOH

With <(Me)3CC6H2(Me)OH>2S; hydrogen; dipyridine chromium trioxide; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja00385a038

Reference yield:

: 83061-04-5
(5R,6S)-5-(2-Benzyloxy-ethyl)-6-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-pyran-2-one

: 83061-06-7
(R)-3-{(2S,3R,5S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: LDA / tetrahydrofuran / -78 deg C -> -40 deg C

2: hydrogen / Pd-C / ethanol

3: CrO₃*2Py / CH₂Cl₂

4: TsOH

With hydrogen; dipyridine chromium trioxide; toluene-4-sulfonic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja00385a038

Reference yield:

: (5R,6S)-5-(2-Benzyloxy-ethyl)-6-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-methyl-tetrahydro-pyran-2-one

: 83061-06-7
(R)-3-{(2S,3R,5S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / Pd-C / ethanol

2: CrO₃*2Py / CH₂Cl₂

3: TsOH

With hydrogen; dipyridine chromium trioxide; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/ja00385a038