(2R,3R)-4,4-difluoro-5-(methylsulfonyloxy)-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate

Base Information

Chemical Name:(2R,3R)-4,4-difluoro-5-(methylsulfonyloxy)-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate
CAS No.:1147119-13-8
Molecular Formula:C₃₂H₂₈F₂O₇S
Molecular Weight:594.633
Hs Code.:

Synonyms:(2R,3R)-4,4-difluoro-5-(methylsulfonyloxy)-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate

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Chemical Property of (2R,3R)-4,4-difluoro-5-(methylsulfonyloxy)-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate

Chemical Property:

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Technology Process of (2R,3R)-4,4-difluoro-5-(methylsulfonyloxy)-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate

There total 8 articles about (2R,3R)-4,4-difluoro-5-(methylsulfonyloxy)-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3R)-4,4-difluoro-5-hydroxy-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate

: 124-63-0
methanesulfonyl chloride

: 1147119-13-8
(2R,3R)-4,4-difluoro-5-(methylsulfonyloxy)-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 10 ℃; for 1h;

Reference yield:

: 1147119-07-0
(3R,4R)-5-trityloxy-3-hydroxy-2,2-difluoro-pentanoic acid γ-lactone

: 1147119-13-8
(2R,3R)-4,4-difluoro-5-(methylsulfonyloxy)-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; pyridine / ethyl acetate / 16 h / 5 - 20 °C

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tert-butyl methyl ether / 1.67 h / 0 - 8 °C / Inert atmosphere

2.2: 8 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 10 °C

With pyridine; dmap; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; tert-butyl methyl ether; ethyl acetate;

Reference yield:

: 76-83-5
trityl chloride

: 1147119-13-8
(2R,3R)-4,4-difluoro-5-(methylsulfonyloxy)-2-(trityloxymethyl)tetrahydrofuran-3-yl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / acetonitrile; water / 70 - 75 °C

1.2: 0 - 55 °C

2.1: dmap; pyridine / ethyl acetate / 16 h / 5 - 20 °C

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tert-butyl methyl ether / 1.67 h / 0 - 8 °C / Inert atmosphere

3.2: 8 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 10 °C

With pyridine; dmap; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; In dichloromethane; tert-butyl methyl ether; water; ethyl acetate; acetonitrile;