3-(4-methoxybenzyl)-5-nitromethylbenzoic acid

Base Information

Chemical Name:3-(4-methoxybenzyl)-5-nitromethylbenzoic acid
CAS No.:869096-88-8
Molecular Formula:C₁₅H₁₃NO₅
Molecular Weight:287.272
Hs Code.:

Synonyms:3-(4-methoxybenzyl)-5-nitromethylbenzoic acid

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Chemical Property of 3-(4-methoxybenzyl)-5-nitromethylbenzoic acid

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Technology Process of 3-(4-methoxybenzyl)-5-nitromethylbenzoic acid

There total 4 articles about 3-(4-methoxybenzyl)-5-nitromethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 869096-83-3
methyl 3-(4-methoxybenzyl)-5-nitromethylbenzoate

: 869096-88-8
3-(4-methoxybenzyl)-5-nitromethylbenzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2008.05.046

Reference yield:

: 869096-81-1
methyl 3-(4-methoxybenzoyl)-5-nitromethylbenzoate

: 869096-88-8
3-(4-methoxybenzyl)-5-nitromethylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / triflic acid; triethylsilane; TFA / CH₂Cl₂ / 20 °C

2: 89 percent / aq. LiOH / tetrahydrofuran; methanol / 20 °C

With triethylsilane; lithium hydroxide; trifluorormethanesulfonic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm050280z

Reference yield:

: 1955-46-0
5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

: 869096-88-8
3-(4-methoxybenzyl)-5-nitromethylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 1 h / Heating

2: 1.78 g / AlCl₃ / CH₂Cl₂ / 120 h / 20 °C

3: 71 percent / triflic acid; triethylsilane; TFA / CH₂Cl₂ / 20 °C

4: 89 percent / aq. LiOH / tetrahydrofuran; methanol / 20 °C

With triethylsilane; lithium hydroxide; aluminium trichloride; thionyl chloride; trifluorormethanesulfonic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; 2: Friedel-Crafts acylation;
DOI:10.1021/jm050280z