1955-46-0

Usage

Chemical Properties

SLIGHTLY YELLOW FINE CRYSTALLINE POWDER

Uses

Different sources of media describe the Uses of 1955-46-0 differently. You can refer to the following data:
1. Methyl 5-nitroisophthalate is used in the preparation of heterotrifunctional crosslinkers for multiple bioconjugation with peptides and also in the synthesis of histone demethylase LSD1 inhibitors tha t target cancer cells.
2. mono-Methyl 5-nitroisophthalate has been used as starting reagent in the synthesis of 3-amide-5-[(dipropylamino)carbonyl]benzoic acids.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C9H7NO6/c1-16-9(13)6-2-5(8(11)12)3-7(4-6)10(14)15/h2-4H,1H3,(H,11,12)/p-1

Upstream product

• 67-56-1 methanol 
• 618-88-2 5-nitrobenzene-1,3-dicarboxylic acid 
• 13290-96-5 dimethyl 5-nitroisophthalate 
• 485-80-3 S-adenosyl-L-methionine 

Downstream Products

• 167215-63-6 3-methanesulfonyloxymethyl-5-nitrobenzoic acid methyl ester 
• 1955-04-0 methyl 5-nitro-3-chloroformylbenzoate 
• 53732-08-4 3-hydroxymethyl-5-nitrobenzoic acid methyl ester 
• 28179-47-7 5-aminoisophthalic acid monomethyl ester 
• 99066-80-5 methyl 3-cyano-5-nitrobenzoate 
• 1056157-87-9 C₁₂H₁₂N₂O₇ 
• 845777-83-5 3-aminomethyl-5-guanidinobenzoic acid 
• 845777-81-3 (Z)-methyl 3-(2,3-bis(tert-butoxycarbonyl)guanidino)-5-cyanobenzoate 
• 845777-82-4 C₂₀H₃₀N₄O₆ 
• 845777-84-6 3-guanidino-5-[(6-{6-[6-(3-tritylsulfanyl-propionylamino)-hexanoylamino]-hexanoylamino}-hexanoylamino)-methyl]-benzoic acid 
• 199536-01-1 methyl 3-amino-5-cyanobenzoate 
• 98556-65-1 3-cyano-5-nitrobenzoic acid 
• 91088-47-0 Methyl 5-Nitro-3-(N,N-dimethyl)carbamoylbenzoate 
• 1056562-53-8 C₁₄H₁₁N₃O₆ 

Relevant academic research and scientific papers

Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis

Carboxyl methyltransferase (CMT) enzymes catalyse the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that the enzyme FtpM from Aspergillus fumigatus can methylate a broad range of aromatic mono- and dicarboxylic acids in good to excellent conversions. The enzyme shows high regioselectivity on its natural substrate fumaryl-l-tyrosine, trans, trans-muconic acid and a number of the dicarboxylic acids tested. Dicarboxylic acids are generally better substrates than monocarboxylic acids, although some substituents are able to compensate for the absence of a second acid group. For dicarboxylic acids, the second methylation shows strong pH dependency with an optimum at pH 5.5–6. Potential for application in industrial biotechnology was demonstrated in a cascade for the production of a bioplastics precursor (FDME) from bioderived 5-hydroxymethylfurfural (HMF).

Preparation technology of iopromide intermediate

The invention provides an iopromide intermediate. A preparation technology of a compound 3-(2,3-dihydroxypropyl formamyl)-5-nitroisophthalic acid comprises the steps that monomethyl 5-nitroisophthalate is reacted with 3-amino propane-1,2-diol in alcohol solvent at appropriate heating temperature on the condition that strong alkali exists to obtain a product, wherein the reaction equation is shown in the specification. According to the preparation technology of the iopromide intermediate, the synthetic technology is good in selectivity, the synthetic route is simple, the product can be obtained through simple filtration, and the yield is high. Therefore, the technology has the advantages of being efficient, rapid and low in cost.

Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABAA receptor

To further develop and evaluate a pharmacophore model previously proposed by Cook and co-workers (Drug Des. Discovery 1995, 12, 193-248) for ligands binding to the benzodiazepine site of the GABAA receptor, 40 new flavone derivatives have been synthesized and their affinities for the benzodiazepine site have been determined. Two new regions of steric repulsive interactions between ligand and receptor have been characterized, and the receptor region in the vicinity of 6- and 3′-substituents has been mapped out. 2′-Hydroxy substitution is shown to give a significant increase in affinity, which is interpreted in terms of a novel hydrogen bond interaction with the previously proposed hydrogen bond-accepting site A2. On the basis of the results of these studies and the refined pharmacophore model, 5′-bromo-2′-hydroxy-6-methylflavone, the highest affinity flavone derivative reported so far (Ki = 0.9 nM), was successfully designed. A comparison of the pharmacophore model with a recently proposed alternative model (Marder; et al. Bioorg. Med. Chem., 2001, 9, 323-335) has been made.

Carboxamide non-ionic contrast media

Novel triiodo 5-aminoisophthaldiamides are provided, where the amino and one of the amide nitrogens are substituted. The compounds have at least two hydroxyl groups and are found to provide low viscosity and osmolality. Procedures for preparing the compounds are provided.

Ureylene naphthalene sulfonic acids

Ureylenebis-symmetrical-phenenylbiscarbonylimino-substituted phenylenecarbonylimino-tetranaphthalenepolysulfonic acid benzoic acid salts, and nitro- and amino-substituted phenylenebiscarbonylimino-substituted benzamido-phenylenedicarbonyl-dinaphthalenepolysulfonic acid benzoic acid salts which are intermediates for the preparation of the active ureides which have complement inhibiting activity.