[5-formyl-2-(3-nitrooxypropoxy)phenyl] 2-(tert-butoxycarbonylamino)acetate

Base Information

Chemical Name:[5-formyl-2-(3-nitrooxypropoxy)phenyl] 2-(tert-butoxycarbonylamino)acetate
CAS No.:1248570-74-2
Molecular Formula:C₁₇H₂₂N₂O₉
Molecular Weight:398.37
Hs Code.:

Synonyms:[5-formyl-2-(3-nitrooxypropoxy)phenyl] 2-(tert-butoxycarbonylamino)acetate

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Chemical Property of [5-formyl-2-(3-nitrooxypropoxy)phenyl] 2-(tert-butoxycarbonylamino)acetate

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Technology Process of [5-formyl-2-(3-nitrooxypropoxy)phenyl] 2-(tert-butoxycarbonylamino)acetate

There total 3 articles about [5-formyl-2-(3-nitrooxypropoxy)phenyl] 2-(tert-butoxycarbonylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 4530-20-5
BOC-glycine

: 1248570-62-8
3-(4-formyl-2-hydroxyphenoxy)propyl nitrate

: 1248570-74-2
[5-formyl-2-(3-nitrooxypropoxy)phenyl] 2-(tert-butoxycarbonylamino)acetate

Guidance literature:: BOC-glycine; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

3-(4-formyl-2-hydroxyphenoxy)propyl nitrate; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/cmdc.201300105

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1248570-74-2
[5-formyl-2-(3-nitrooxypropoxy)phenyl] 2-(tert-butoxycarbonylamino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydrogencarbonate / acetonitrile / 4 h / 70 °C

2.1: silver nitrate / acetonitrile / 14 h / 70 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

With dmap; potassium hydrogencarbonate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1002/cmdc.201300105

Reference yield:

: 1248570-61-7
4-(3-bromopropoxy)-3-hydroxybenzaldehyde

: 1248570-74-2
[5-formyl-2-(3-nitrooxypropoxy)phenyl] 2-(tert-butoxycarbonylamino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver nitrate / acetonitrile / 14 h / 70 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With dmap; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1002/cmdc.201300105