Technology Process of 18-acetoxy-1α-hydroxyvitamin D3
There total 7 articles about 18-acetoxy-1α-hydroxyvitamin D3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
Ambient temperature;
DOI:10.1021/jo00037a046
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 91 percent / Pb(OAc)4, pyridine / benzene / 2.5 h / Ambient temperature; Irradiation
2: 1.) BF3*Et2O / 1.) ether, -20 deg C, 0.5 h, 2.) r. t., 0.5 h
3: 73 percent / K2CO3 / methanol / 1 h / Ambient temperature
4: 87 percent / pyridinium dichromate (PDC), pyridinium trifluoroacetate (PTFA) / CH2Cl2 / 4 h
5: 1.) n-BuLi / 1.) hexanes, THF, -78 deg C, 2.) THF, -78 deg C
6: 75 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature
With
pyridine; lead(IV) acetate; dipyridinium dichromate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium trifluroacetate; potassium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jo00037a046
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / LiAlH4 / diethyl ether
2: 91 percent / Pb(OAc)4, pyridine / benzene / 2.5 h / Ambient temperature; Irradiation
3: 1.) BF3*Et2O / 1.) ether, -20 deg C, 0.5 h, 2.) r. t., 0.5 h
4: 73 percent / K2CO3 / methanol / 1 h / Ambient temperature
5: 87 percent / pyridinium dichromate (PDC), pyridinium trifluoroacetate (PTFA) / CH2Cl2 / 4 h
6: 1.) n-BuLi / 1.) hexanes, THF, -78 deg C, 2.) THF, -78 deg C
7: 75 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature
With
pyridine; lead(IV) acetate; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium trifluroacetate; potassium carbonate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1021/jo00037a046
