tert-butyl {[6-(2,5-dioxopiperazin-1-yl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

Base Information

Chemical Name:tert-butyl {[6-(2,5-dioxopiperazin-1-yl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate
CAS No.:660451-50-3
Molecular Formula:C₃₀H₃₆N₄O₄
Molecular Weight:516.64
Hs Code.:

Synonyms:tert-butyl {[6-(2,5-dioxopiperazin-1-yl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

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Chemical Property of tert-butyl {[6-(2,5-dioxopiperazin-1-yl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

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Technology Process of tert-butyl {[6-(2,5-dioxopiperazin-1-yl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

There total 13 articles about tert-butyl {[6-(2,5-dioxopiperazin-1-yl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 660451-49-0
tert-butyl N-[(benzyloxy)carbonyl]glycyl-N-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]glycinate

: 660451-50-3
tert-butyl {[6-(2,5-dioxopiperazin-1-yl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

Guidance literature:: tert-butyl N-[(benzyloxy)carbonyl]glycyl-N-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]glycinate; With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 24h;

for 17h; Heating / reflux;

Reference yield:

: C₃₄H₄₆N₄O₅

: 660451-50-3
tert-butyl {[6-(2,5-dioxopiperazin-1-yl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

Guidance literature:: In ethanol; for 17h; Reflux;
DOI:10.1016/j.bmc.2011.06.032

Reference yield:

: 304854-54-4
2-amino-5-bromo-N-methoxy-N-methyl-benzamide

: 660451-50-3
tert-butyl {[6-(2,5-dioxopiperazin-1-yl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran; diethyl ether / 0 °C

2.1: methanesulfonic acid / toluene / 6 h / Reflux

3.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 1 h / 90 °C / Inert atmosphere

4.1: ammonia; hydrogen / tetrahydrofuran; methanol; water / 6 h / 20 °C / 3750.38 Torr

5.1: tetrahydrofuran / 0.5 h / 20 °C

6.1: pyridine / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

6.2: 60 h / 20 °C

7.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C / 760.05 Torr

8.1: ethanol / 17 h / Reflux

With pyridine; methanesulfonic acid; palladium 10% on activated carbon; ammonia; hydrogen; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; 2.1: Friedlaender synthesis;
DOI:10.1016/j.bmc.2011.06.032