Glycine, N-[(phenylmethoxy)carbonyl]glycyl-N-[3-[[[(1,1-dimethylethoxy)carbonyl] amino]methyl]-4-(4-methylphenyl)-2-(2-methylpropyl)-6-quinolinyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Glycine, N-[(phenylmethoxy)carbonyl]glycyl-N-[3-[[[(1,1-dimethylethoxy)carbonyl] amino]methyl]-4-(4-methylphenyl)-2-(2-methylpropyl)-6-quinolinyl]-, 1,1-dimethylethyl ester
CAS No.:660451-49-0
Molecular Formula:C42H52N4O7
Molecular Weight:724.897
Hs Code.:

Glycine,
N-[(phenylmethoxy)carbonyl]glycyl-N-[3-[[[(1,1-dimethylethoxy)carbonyl]
amino]methyl]-4-(4-methylphenyl)-2-(2-methylpropyl)-6-quinolinyl]-,
1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Glycine, N-[(phenylmethoxy)carbonyl]glycyl-N-[3-[[[(1,1-dimethylethoxy)carbonyl] amino]methyl]-4-(4-methylphenyl)-2-(2-methylpropyl)-6-quinolinyl]-, 1,1-dimethylethyl ester

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Technology Process of Glycine, N-[(phenylmethoxy)carbonyl]glycyl-N-[3-[[[(1,1-dimethylethoxy)carbonyl] amino]methyl]-4-(4-methylphenyl)-2-(2-methylpropyl)-6-quinolinyl]-, 1,1-dimethylethyl ester

There total 11 articles about Glycine, N-[(phenylmethoxy)carbonyl]glycyl-N-[3-[[[(1,1-dimethylethoxy)carbonyl] amino]methyl]-4-(4-methylphenyl)-2-(2-methylpropyl)-6-quinolinyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 660451-48-9
tert-butyl N-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]glycinate

: 15050-24-5
N-(benzyloxycarbonyl)glycyl chloride

: 660451-49-0
tert-butyl N-[(benzyloxy)carbonyl]glycyl-N-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]glycinate

Guidance literature:: tert-butyl N-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]glycinate; N-(benzyloxycarbonyl)glycyl chloride; With pyridine; In tetrahydrofuran; for 1h;

With dmap; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

: 304854-54-4
2-amino-5-bromo-N-methoxy-N-methyl-benzamide

: 660451-49-0
tert-butyl N-[(benzyloxy)carbonyl]glycyl-N-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]glycinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; diethyl ether / 0 °C

2.1: methanesulfonic acid / toluene / 6 h / Reflux

3.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 1 h / 90 °C / Inert atmosphere

4.1: ammonia; hydrogen / tetrahydrofuran; methanol; water / 6 h / 20 °C / 3750.38 Torr

5.1: tetrahydrofuran / 0.5 h / 20 °C

6.1: pyridine / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

6.2: 60 h / 20 °C

With pyridine; methanesulfonic acid; ammonia; hydrogen; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; toluene; 2.1: Friedlaender synthesis;
DOI:10.1016/j.bmc.2011.06.032

Reference yield:

: 660451-32-1
6-bromo-4-(4-methylphenyl)-2-(2-methylpropyl)quinoline-3-carbonitrile

: 660451-49-0
tert-butyl N-[(benzyloxy)carbonyl]glycyl-N-[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]glycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 1 h / 90 °C / Inert atmosphere

2.1: ammonia; hydrogen / tetrahydrofuran; methanol; water / 6 h / 20 °C / 3750.38 Torr

3.1: tetrahydrofuran / 0.5 h / 20 °C

4.1: pyridine / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 60 h / 20 °C

With pyridine; ammonia; hydrogen; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.032