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N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester

Base Information Edit
  • Chemical Name:N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester
  • CAS No.:1003316-10-6
  • Molecular Formula:C25H25ClN2O3
  • Molecular Weight:436.938
  • Hs Code.:
  • Mol file:1003316-10-6.mol
N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester

Synonyms:tert-butyl 3-(4-(chloromethyl)benzamido)biphenyl-4-ylcarbamate

Suppliers and Price of N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • N-[3-[[4-(Chloromethyl)benzoyl]amino][1,1''-biphenyl]-4-yl]carbamicAcidtert-ButylEster
  • 500mg
  • $ 1540.00
  • Medical Isotopes, Inc.
  • N-[3-[[4-(Chloromethyl)benzoyl]amino][1,1??-biphenyl]-4-yl]carbamicAcidtert-ButylEster
  • 50 mg
  • $ 675.00
Total 2 raw suppliers
Chemical Property of N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester Edit
Chemical Property:
  • Storage Temp.:Refrigerator 
  • Solubility.:Chloroform, Dichloromethane, Methanol 
Purity/Quality:

99% *data from raw suppliers

N-[3-[[4-(Chloromethyl)benzoyl]amino][1,1''-biphenyl]-4-yl]carbamicAcidtert-ButylEster *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Uses N-[3-[[4-(Aminomethyl)benzoyl]amino][1,1''-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is a reactant used in the preparation of carboxybenzylamino biaryls as histone deacetylase inhibitors and in the optimization of biaryl selective HDAC1&2 inhibitors. N-[3-[[4-(Aminomethyl)benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is a reactant used in the preparation of carboxybenzylamino biaryls as histone deacetylase inhibitors and in the optimization of biaryl selective HDAC1&2 inhibitors.
Technology Process of N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester

There total 5 articles about N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 4 steps
1: triethylamine; dmap / dichloromethane / 15 h / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran / 15 h / Reflux
3: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C
4: triethylamine / dichloromethane / 3 h / 20 °C
With dmap; tetrakis(triphenylphosphine) palladium(0); palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 2: |Suzuki Coupling;
DOI:10.1002/bkcs.12254
Guidance literature:
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran / 15 h / Reflux
2: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C
3: triethylamine / dichloromethane / 3 h / 20 °C
With tetrakis(triphenylphosphine) palladium(0); palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1: |Suzuki Coupling;
DOI:10.1002/bkcs.12254
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