Norethandrolone

Base Information

• Chemical Name: Norethandrolone
• CAS No.: 52-78-8
• Molecular Formula: C20H30O2
• Molecular Weight: 302.457
• European Community (EC) Number: 200-153-5
• NSC Number: 70581,9893
• UNII: P7W01638W6
• DSSTox Substance ID: DTXSID0023379
• Nikkaji Number: J4.135A
• Wikipedia: Norethandrolone
• Wikidata: Q7050955
• NCI Thesaurus Code: C80802
• Metabolomics Workbench ID: 153710
• ChEMBL ID: CHEMBL1697845
• Mol file: 52-78-8.mol

Synonyms:Ethylestrenolone;Ethylnortestosterone;Nilevar;Norethandrolone

Chemical Property of Norethandrolone

Chemical Property:

• Vapor Pressure: 7.11E-10mmHg at 25°C
• Melting Point: 130-136°C
• Refractive Index: 1.555
• Boiling Point: 447.136 °C at 760 mmHg
• PKA: 15.13±0.40(Predicted)
• Flash Point: 190.529 °C
• PSA: 37.30000
• Density: 1.107 g/cm³
• LogP: 4.26930
• Storage Temp.: ?20°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 302.224580195
• Heavy Atom Count: 22
• Complexity: 522

Purity/Quality:

99% ^*data from raw suppliers

NORETHANDROLONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 60-61-11-19-38
• Safety Statements: 53-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C)O
• Isomeric SMILES: CC[C@@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@H]34)C)O
• Recent ClinicalTrials: Treatment Outcome in Elderly Patients
• Uses: Norethandrolone is antinauseant and antiemetic highly specific and selective serotonin subtype 3 (5-HT3) receptor antagonist Controlled substance (anabolic steroid). Androgen.
• Therapeutic Function: Androgen

Technology Process of Norethandrolone

There total 12 articles about Norethandrolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

norethisterone (68-22-4) → norethandrolone (52-78-8)

Guidance literature:

With 1,4-dioxane; palladium on activated charcoal; Hydrogenation;

DOI:10.1021/ja01562a028

Reference yield:

diethyl ether ethyl acetate + 3-methoxy-19-nor-17βH-pregna-2,5(10)-dien-17-ol (1042-57-5) → norethandrolone (52-78-8)

Guidance literature:

With hydrogenchloride; In methanol; water;

Reference yield:

3-methoxy-19-nor-17βH-pregna-2,5(10)-dien-17-ol (1042-57-5) → norethandrolone (52-78-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01562a028

upstream raw materials:

norethisterone

estra-4-ene-3,17-dione

3-methoxy-19-nor-17βH-pregna-2,5(10)-dien-17-ol

3,3-ethanediyldioxy-17ξ-hydroxy-estr-5-ene-17ξ-carbonitrile

Downstream raw materials:

17α-ethyl-17β-hydroxy-5-methyl-5α-estran-2-one

19-nor-5α,17α-pregnane-3β,17β-diol

17β-hydroxy-19-nor-5β,17α-pregnan-3-one

19-nor-5α,17α-pregnane-3α,17β-diol

Refernces

Positional isomers of mannose-quinoline conjugates and their copper complexes: Exploring the biological activity

10.1039/c8nj00993g

This study aimed to develop novel 8-hydroxyquinoline (HQ) derivatives with improved pharmacological properties. Three positional isomers of mannose-HQ conjugates (ManHQ2, ManHQ5, and ManHQ7) ??and one glucose-HQ conjugate (GlcHQ7) were synthesized to explore the effects of sugar type and position on biological activity. ManHQ2 was synthesized using 8-hydroxyquinoline-2-carboxylic acid (HQ2) as the starting material. ManHQ5 was synthesized using 8-hydroxyquinoline-5-carboxylic acid (HQ5) as the starting material. ManHQ7 and GlcHQ7 were synthesized using 8-hydroxyquinoline-7-carboxylic acid (HQ7) as the starting material. 8-Hydroxyquinoline-2-carboxamide (CAHQ2) was used as a reference compound for antimicrobial activity testing. These compounds were characterized by nuclear magnetic resonance spectroscopy, electrospray ionization mass spectrometry (ESI-MS), and UV-visible spectroscopy. The study found that these conjugates exhibited significant antioxidant and antibacterial activities, with specific isomers showing significant antibacterial effects against Pseudomonas aeruginosa and Staphylococcus aureus. In addition, ManHQ2 exhibited antiproliferative activity against human tumor cells in the presence of copper (II) ions. The results suggest that these HQ mannose conjugates have the potential to be bioactive molecules and have increased biocompatibility, which can be further explored for their use as antibiotics and cancer treatments.