1-[2-(2,4-Dichloro-phenyl)-ethyl]-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

Base Information

Chemical Name:1-[2-(2,4-Dichloro-phenyl)-ethyl]-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea
CAS No.:184003-42-7
Molecular Formula:C₂₇H₂₅Cl₂N₃O₄S
Molecular Weight:558.485
Hs Code.:

Synonyms:1-[2-(2,4-Dichloro-phenyl)-ethyl]-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

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Chemical Property of 1-[2-(2,4-Dichloro-phenyl)-ethyl]-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

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Technology Process of 1-[2-(2,4-Dichloro-phenyl)-ethyl]-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

There total 5 articles about 1-[2-(2,4-Dichloro-phenyl)-ethyl]-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 184003-30-3
2-(2,4-dichlorophenyl)ethyl isothiocyanate

: 2-[2-(4-Aminomethyl-2-methoxy-phenoxy)-ethyl]-isoindole-1,3-dione; compound with trifluoro-acetic acid

: 184003-42-7
1-[2-(2,4-Dichloro-phenyl)-ethyl]-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

Guidance literature:: With triethylamine; In ethyl acetate;
DOI:10.1021/jm960512h

Reference yield:

: 7149-10-2
vanillylamine hydrochloride

: 184003-42-7
1-[2-(2,4-Dichloro-phenyl)-ethyl]-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / Et₃N / H₂O; dioxane / Ambient temperature

2: 77 percent / 40percent aq. KOH, 40percent aq. tetrabutylammonium hydroxide / 3 h / 50 °C

3: 97 percent / dimethylformamide / 2 h / 50 °C

4: 90 percent / CH₂Cl₂ / 2 h / Ambient temperature

5: 44 percent / Et₃N / ethyl acetate

With potassium hydroxide; tetra(n-butyl)ammonium hydroxide; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm960512h

Reference yield:

: 130972-89-3
(4-hydroxy-3-methoxybenzyl)carbamic acid tert-butyl ester

: 184003-42-7
1-[2-(2,4-Dichloro-phenyl)-ethyl]-3-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / 40percent aq. KOH, 40percent aq. tetrabutylammonium hydroxide / 3 h / 50 °C

2: 97 percent / dimethylformamide / 2 h / 50 °C

3: 90 percent / CH₂Cl₂ / 2 h / Ambient temperature

4: 44 percent / Et₃N / ethyl acetate

With potassium hydroxide; tetra(n-butyl)ammonium hydroxide; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm960512h