N-(3-(5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide
CAS No.:1254783-25-9
Molecular Formula:C₂₀H₁₅N₅O₂
Molecular Weight:357.371
Hs Code.:

Synonyms:N-(3-(5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

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Chemical Property of N-(3-(5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

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Technology Process of N-(3-(5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

There total 8 articles about N-(3-(5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254783-96-4
N-(3-(7-(hydroxymethyl)-5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

: 1254783-25-9
N-(3-(5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; for 2h;

Reference yield:

: 1265527-37-4
C₁₇H₂₁ClN₄OSi

: 1254783-25-9
N-(3-(5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 100 °C

2: trifluoroacetic acid / dichloromethane

3: N-ethyl-N,N-diisopropylamine / dichloromethane

4: sodium hydrogencarbonate / tetrahydrofuran; water

With sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2010.12.036

Reference yield:

: 1207543-30-3
4‐chloro‐5‐iodo‐7‐((2‐(trimethylsilyl)ethoxy)methyl)‐7H‐pyrrolo[2,3‐d]pyrimidine

: 1254783-25-9
N-(3-(5-(pyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water

2: potassium carbonate / dimethyl sulfoxide / 100 °C

3: trifluoroacetic acid / dichloromethane

4: N-ethyl-N,N-diisopropylamine / dichloromethane

5: sodium hydrogencarbonate / tetrahydrofuran; water

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.036