tert-butyl-3-(5-(pyridin-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate

Base Information

Chemical Name:tert-butyl-3-(5-(pyridin-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate
CAS No.:1254783-94-2
Molecular Formula:C₂₈H₃₅N₅O₄Si
Molecular Weight:533.702
Hs Code.:

Synonyms:tert-butyl-3-(5-(pyridin-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate

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Chemical Property of tert-butyl-3-(5-(pyridin-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate

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Technology Process of tert-butyl-3-(5-(pyridin-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate

There total 5 articles about tert-butyl-3-(5-(pyridin-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254783-93-1
tert-butyl-3-(5-iodo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate

: 1692-25-7
3-pyridylboronic acid

: 1254783-94-2
tert-butyl-3-(5-(pyridin-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 100 ℃; for 1h;

Reference yield:

: 1265527-37-4
C₁₇H₂₁ClN₄OSi

: 19962-06-2
tert-butyl 3-hydroxyphenylcarbamate

: 1254783-94-2
tert-butyl-3-(5-(pyridin-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 100 ℃;
DOI:10.1016/j.bmcl.2010.12.036

Reference yield:

: 1207543-30-3
4‐chloro‐5‐iodo‐7‐((2‐(trimethylsilyl)ethoxy)methyl)‐7H‐pyrrolo[2,3‐d]pyrimidine

: 1254783-94-2
tert-butyl-3-(5-(pyridin-3-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water

2: potassium carbonate / dimethyl sulfoxide / 100 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; potassium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.036