CID 10532254

Base Information

Chemical Name:CID 10532254
CAS No.:132866-11-6
Molecular Formula:C36H42ClN3O6
Molecular Weight:648.199
Hs Code.:
Mol file:132866-11-6.mol

Synonyms:

Suppliers and Price of CID 10532254

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Lercanidipine Hydrochloride
10mg
$ 135.00

Tocris
Lercanidipine Hydrochloride ≥99%(HPLC)
50
$ 388.00

Tocris
Lercanidipine Hydrochloride ≥99%(HPLC)
10
$ 92.00

TCI Chemical
Lercanidipine Hydrochloride >98.0%(HPLC)(T)
200mg
$ 13.00

TCI Chemical
Lercanidipine Hydrochloride >98.0%(HPLC)(T)
1g
$ 38.00

Sigma-Aldrich
Lercanidipine hydrochloride ≥98% (HPLC)
10mg
$ 171.00

Sigma-Aldrich
Lercanidipine hydrochloride ≥98% (HPLC)
50mg
$ 673.00

Medical Isotopes, Inc.
LercanidipineHCl
0.5 g
$ 1500.00

Medical Isotopes, Inc.
Lercanidipine-d3HCl
5 mg
$ 1490.00

DC Chemicals
LercanidipineHCl >98%
1 g
$ 300.00

Total 143 raw suppliers

Chemical Property of CID 10532254

Chemical Property:

Appearance/Colour:pale-yellow powder
Vapor Pressure:3.77E-20mmHg at 25°C
Melting Point:175-177 °C
Boiling Point:712.5 °C at 760 mmHg
Flash Point:384.7 °C
PSA：113.69000
LogP:8.13240
Storage Temp.:2-8°C
Solubility.:soluble in Methanol
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:13
Exact Mass:647.2762138
Heavy Atom Count:46
Complexity:1090

Purity/Quality:

99.5%min ^*data from raw suppliers

Lercanidipine Hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 25
Safety Statements: 36/37-45

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)C[NH+](C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.[Cl-]
Uses A dihydropyridine calcium channel blocker. Antihypertensive. long-acting dihydropyridine calcium channel blocker, antihypertensive
Clinical Use #N/A
Drug interactions Potentially hazardous interactions with other drugs Aminophylline and theophylline: possibly increased aminophylline and theophylline concentration. Anaesthetics: enhanced hypotensive effect. Antibacterials: metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin - avoid with erythromycin. Antidepressants: enhanced hypotensive effect with MAOIs. Antiepileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone. Antifungals: metabolism possibly inhibited by itraconazole and ketoconazole - avoid; negative inotropic effect possibly increased with itraconazole. Antihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of postsynaptic alpha-blockers. Antivirals: concentration increased by ritonavir - avoid. Cardiac glycosides: digoxin concentration increased. Ciclosporin: concentration of both drugs may be increased - avoid. Grapefruit juice: concentration increased - avoid

Technology Process of CID 10532254

There total 11 articles about CID 10532254 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 957215-03-1
(R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate

: 132866-11-6,184866-29-3
lercanidipine hydrochloride

Guidance literature:: (R,S) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester oxalate; With potassium carbonate; In dichloromethane; water;

With hydrogenchloride; In dichloromethane; water;

Reference yield: 90.0%

: 100427-26-7
lercanidipine

: 132866-11-6,184866-29-3
lercanidipine hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; tert-butyl methyl ether; Product distribution / selectivity;

Reference yield: 42.0%

: 21731-17-9
methyl 3-aminocrotonate

: 132866-11-6,184866-29-3
lercanidipine hydrochloride

Guidance literature:: 2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethyl ethyl ester hydrochloride; With triethylamine; In propan-1-ol; dichloromethane; at 25 - 30 ℃; pH=~ 8 - ~ 9;

methyl 3-aminocrotonate; In propan-1-ol; dichloromethane; at 75 - 80 ℃; for 10h;

With hydrogenchloride; In propan-1-ol; at 20 - 30 ℃; for 0.5h; pH=~ 3 - ~ 4;