(Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol

Base Information

• Chemical Name: (Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol
• CAS No.: 1612882-65-1
• Molecular Formula: C₁₆H₁₂F₆N₂O₂S
• Molecular Weight: 410.34

Synonyms:(Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol

Chemical Property of (Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol

Chemical Property:

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Technology Process of (Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol

There total 3 articles about (Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-Aminomethylthiophene (27757-85-3) + 3-bromo-1,1,1-trifluoroacetone (431-35-6) + 4-(trifluoromethyl)phenyl isothiocyanate (1645-65-4) → (Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol (1612882-65-1)

Guidance literature:

2-Aminomethylthiophene; 4-(trifluoromethyl)phenyl isothiocyanate; In N,N-dimethyl-formamide; for 0.0833333h;

3-bromo-1,1,1-trifluoroacetone; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/ejoc.201301710

Reference yield: 87.0%

furan-2-ylmethanamine (617-89-0) + 3-bromo-1,1,1-trifluoroacetone (431-35-6) + 4-(trifluoromethyl)phenyl isothiocyanate (1645-65-4) → (Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol (1612882-65-1)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1039/c5md00603a

Reference yield:

furan-2-ylmethanamine (617-89-0) + 4-(trifluoromethyl)phenyl isothiocyanate (1645-65-4) + 3-bromo-1,1,1-trifluoromethylpropanone → (Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol (1612882-65-1)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

2-Aminomethylthiophene

3-bromo-1,1,1-trifluoroacetone

4-(trifluoromethyl)phenyl isothiocyanate

furan-2-ylmethanamine

Downstream raw materials:

(Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

(Z)-N-(4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

(Z)-N-cyclohexyl-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

(Z)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]-N-(thiophen-2-ylmethyl)acetamide

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