(Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

Base Information

Chemical Name:(Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide
CAS No.:1612882-77-5
Molecular Formula:C₂₇H₂₀ClF₇N₆O₃S
Molecular Weight:677.002
Hs Code.:

(Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

Synonyms:(Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

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Chemical Property of (Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

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Technology Process of (Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

There total 7 articles about (Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1093981-49-7
C₈H₆ClFN₄O

: (Z)-N-[3-(furan-2-ylmethyl)-4-(prop-2-ynyloxy)-4-(trifluoromethyl)thiazolidin-2-ylidene]-4-(trifluoromethyl)aniline

: 1612882-77-5
(Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/ejoc.201301710

Reference yield:

: 1645-65-4
4-(trifluoromethyl)phenyl isothiocyanate

: 1612882-77-5
(Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 0.08 h

1.2: 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: copper(l) iodide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201301710

Reference yield:

: 1612882-65-1
(Z)-3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-ol

: 1612882-77-5
(Z)-N-(3-chloro-4-fluorophenyl)-2-[4-({3-(furan-2-ylmethyl)-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenylimino]thiazolidin-4-yloxy}methyl)-1H-1,2,3-triazol-1-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: copper(l) iodide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201301710