<2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester

Base Information

Chemical Name:<2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester
CAS No.:161458-89-5
Molecular Formula:C₁₇H₂₄BrNO₂S
Molecular Weight:386.353
Hs Code.:

Synonyms:<2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester

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Chemical Property of <2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester

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Technology Process of <2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester

There total 7 articles about <2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 161458-88-4
5-((2R,3R,4S)-3-Bromo-4-{[1-phenyl-meth-(E)-ylidene]-amino}-tetrahydro-thiophen-2-yl)-pentanoic acid methyl ester

: 161458-89-5
<2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester

Guidance literature:: With buffer: citric acid pH 4; sodium cyanoborohydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1021/jo00107a009

Reference yield:

: 5-<4(S)-Amino-3(R)-bromotetrahydrothiophen-2(R)-yl>pentanoic acid methyl ester hydrobromide

: 161458-89-5
<2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / aq. NaHCO₃, MgSO₄ / CH₂Cl₂ / 12 h / Ambient temperature

2: 95 percent / NaCNBH₃, buffer: citric acid pH 4 / tetrahydrofuran / 0.33 h / 0 °C

With buffer: citric acid pH 4; sodium cyanoborohydride; sodium hydrogencarbonate; magnesium sulfate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00107a009

Reference yield:

: 100-52-7
benzaldehyde

: 161458-89-5
<2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / aq. NaHCO₃, MgSO₄ / CH₂Cl₂ / 12 h / Ambient temperature

2: 95 percent / NaCNBH₃, buffer: citric acid pH 4 / tetrahydrofuran / 0.33 h / 0 °C

With buffer: citric acid pH 4; sodium cyanoborohydride; sodium hydrogencarbonate; magnesium sulfate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00107a009