2-{4-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol

Base Information

Chemical Name:2-{4-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol
CAS No.:936140-13-5
Molecular Formula:C₅₃H₇₂O₈Si
Molecular Weight:865.235
Hs Code.:

2-{4-benzyloxy-6-[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol

Synonyms:2-{4-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol

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Chemical Property of 2-{4-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol

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Technology Process of 2-{4-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol

There total 1 articles about 2-{4-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 215120-34-6
(2R,3S,4R,6R)-2-[(2S,4S,5R,6S)-4-Benzyloxy-6-(2-hydroxy-ethyl)-5-methyl-tetrahydro-pyran-2-ylmethyl]-2-methoxy-6-[(R)-2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol

: 936140-13-5
2-{4-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetlet.2007.02.003

Reference yield: 86.0%

: 936140-13-5
2-{4-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol

: 74-88-4
methyl iodide

: 936140-14-6
[2-(4-benzyloxy-6-{2,3-dimethoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-2-ylmethyl}-3-methyl-tetrahydro-pyran-2-yl)-ethoxy]-tert-butyl-diphenyl-silane

Guidance literature:: With sodium hydride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetlet.2007.02.003

Reference yield:

: 936140-13-5
2-{4-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-pyran-2-ylmethyl}-2-methoxy-6-[2-(4-methoxy-benzyloxy)-1,1-dimethyl-but-3-enyl]-4-methyl-tetrahydro-pyran-3-ol

: 15-benzyloxy-7-hydroxy-10-methoxy-6,6,9,16-tetramethyl-5-vinyl-4,17-dioxa-bicyclo[11.3.1]heptadecane-3,11-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 86 percent / NaH / CH₂Cl₂ / 20 °C

2.1: 93 percent / TBAF / tetrahydrofuran / 0 °C

3.1: 83 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -75 - 0 °C

4.1: 87 percent / DDQ; H₂O / CH₂Cl₂ / 20 °C

5.1: 89 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / propan-2-ol; H₂O / 0 °C

6.1: 2,4,6-trichlorobenzoyl chloride; iPr₂NEt / tetrahydrofuran / 20 °C

6.2: DMAP / toluene / 60 °C

6.3: 50 percent / HCl / CDCl₃ / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; 2,4,6-trichlorobenzoyl chloride; tetrabutyl ammonium fluoride; water; sodium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; 3.1: Swern oxidation;
DOI:10.1016/j.tetlet.2007.02.003