carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(N'-tert-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester

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Chemical Name:carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(N'-tert-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester
CAS No.:383397-22-6
Molecular Formula:C₄₆H₇₈N₆O₁₁Si
Molecular Weight:919.244
Hs Code.:

carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(<i>N</i>'-<i>tert</i>-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester

Synonyms:carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(N'-tert-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester

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Chemical Property of carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(N'-tert-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester

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Technology Process of carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(N'-tert-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester

There total 17 articles about carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(N'-tert-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3123-97-5
dihydro-5,5-dimethyl-2(3H)-furanone

: 383397-22-6
carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(N'-tert-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: aq. NaOH / ethanol / 2 h / Heating

2: 3.05 g / diethyl ether / 2 h / 0 °C

3: 90 percent / 2,6-lutidine / CH₂Cl₂ / 14.5 h / 0 - 20 °C

4: 91 percent / LiOH*H₂O / H₂O; tetrahydrofuran; methanol / 3.25 h / 0 - 20 °C

5: Et₃N / tetrahydrofuran / 1 h / -78 - 0 °C

6: 1.03 percent / Et₃N; DMAP / tetrahydrofuran / 14 h / 20 °C

7: 99 percent / DMAP / CH₂Cl₂ / 4 h / 20 °C

8: 91 percent / LiOH; aq. H₂O₂ / tetrahydrofuran / 1.25 h / 0 °C

9: 80 percent / DCC; HOBt

10: 99 percent / Pd(PPh₃)4; morpholine

11: DCC; HOBt*H₂O / CH₂Cl₂ / 0 - 20 °C

With morpholine; 2,6-dimethylpyridine; dmap; lithium hydroxide; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo015953+

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 383397-22-6
carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(N'-tert-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / DCC; HOBt hydrate / CH₂Cl₂ / 1 h / 0 °C

2: H₂ / Pd/C / methanol / 2 h

3: BOP-Cl; i-Pr₂EtN / CH₂Cl₂ / 18.5 h / 0 - 20 °C

4: H₂ / Pd/C / methanol / 0.5 h / 20 °C

5: 345 mg / BOP-Cl; i-Pr₂EtN / CH₂Cl₂ / 14.5 h / 0 - 20 °C

6: H₂ / Pd/C / methanol / 2 h

7: DCC; HOBt*H₂O / CH₂Cl₂ / 0 - 20 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo015953+

Reference yield:

: 187753-72-6
Cbz-MeAla-NHNH-Boc

: 383397-22-6
carbonic acid benzyl ester 1-(2-{1-[(1-{[2-(N'-tert-butoxycarbonyl-hydrazino)-1-methyl-2-oxo-ethyl]-methyl-carbamoyl}-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butylcarbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-3-triethylsilanyloxy-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / methanol / 2 h

2: BOP-Cl; i-Pr₂EtN / CH₂Cl₂ / 18.5 h / 0 - 20 °C

3: H₂ / Pd/C / methanol / 0.5 h / 20 °C

4: 345 mg / BOP-Cl; i-Pr₂EtN / CH₂Cl₂ / 14.5 h / 0 - 20 °C

5: H₂ / Pd/C / methanol / 2 h

6: DCC; HOBt*H₂O / CH₂Cl₂ / 0 - 20 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo015953+