methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Base Information

• Chemical Name: methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
• CAS No.: 294198-00-8
• Molecular Formula: C₂₆H₂₇NO₃
• Molecular Weight: 401.505
• Mol file: 294198-00-8.mol

Synonyms:methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Chemical Property of methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

There total 2 articles about methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

dimedone (126-81-8) + acetoacetic acid methyl ester (105-45-3) + 4-Phenylbenzaldehyde (3218-36-8) → methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (294198-00-8)

Guidance literature:

With 1-methylimidazolium trinitromethanide; ammonium acetate; In neat (no solvent); at 20 ℃; for 0.0833333h; Green chemistry;

DOI:10.1039/c4ra09117e

Reference yield:

→ methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (294198-00-8)

Guidance literature:

Reference yield: 75.0%

methyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (294198-00-8) → 4-([1,1’-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid (1394961-64-8,1394961-65-9,1408382-80-8)

Guidance literature:

With boron trichloride; In dichloromethane; at 20 ℃;

DOI:10.1021/jm301144g

upstream raw materials:

dimedone

acetoacetic acid methyl ester

4-Phenylbenzaldehyde

Downstream raw materials:

4-([1,1’-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid