N₂-(4-fluorophenyl)-N₄-isopropyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine-2,4-diamine

Base Information

• Chemical Name: N₂-(4-fluorophenyl)-N₄-isopropyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine-2,4-diamine
• CAS No.: 1447225-57-1
• Molecular Formula: C₁₇H₁₈FN₅O
• Molecular Weight: 327.361

Synonyms:N₂-(4-fluorophenyl)-N₄-isopropyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine-2,4-diamine

Chemical Property of N₂-(4-fluorophenyl)-N₄-isopropyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(4-fluorophenyl)-N₄-isopropyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine-2,4-diamine

There total 5 articles about N₂-(4-fluorophenyl)-N₄-isopropyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethyl orthoacetate (1445-45-0) + 6-((4-fluorophenyl)amino)-4-(isopropylamino)nicotinohydrazide → N2-(4-fluorophenyl)-N4-isopropyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine-2,4-diamine (1447225-57-1)

Guidance literature:

With toluene-4-sulfonic acid; at 100 ℃;

Reference yield:

6-chloro-4-isopropylamino-nicotinic acid ethyl ester (1011464-52-0) → N2-(4-fluorophenyl)-N4-isopropyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine-2,4-diamine (1447225-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 115 °C

2: hydrazine hydrate / ethanol / 3 h / 80 °C

3: toluene-4-sulfonic acid / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water;

Reference yield:

ethyl 4,6-dichloronicotinate (40296-46-6) → N2-(4-fluorophenyl)-N4-isopropyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine-2,4-diamine (1447225-57-1)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 3 h / 120 °C / Sealed tube

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 115 °C

3: hydrazine hydrate / ethanol / 3 h / 80 °C

4: toluene-4-sulfonic acid / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; water;

upstream raw materials:

C₁₇H₂₀FN₃O₂

Trimethyl orthoacetate

6-chloro-4-isopropylamino-nicotinic acid ethyl ester

ethyl 4,6-dichloronicotinate

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