(-)-di-(1S,2R,5S)-menthyl (R_S,S_C)-1-phenyl-1-(p-tolylsulfinylamino)-methanephosphonate

Base Information

• Chemical Name: (-)-di-(1S,2R,5S)-menthyl (R_S,S_C)-1-phenyl-1-(p-tolylsulfinylamino)-methanephosphonate
• CAS No.: 1567841-00-2
• Molecular Formula: C₃₄H₅₂NO₄PS
• Molecular Weight: 601.831
• Mol file: 1567841-00-2.mol

Synonyms:(-)-di-(1S,2R,5S)-menthyl (R_S,S_C)-1-phenyl-1-(p-tolylsulfinylamino)-methanephosphonate

Chemical Property of (-)-di-(1S,2R,5S)-menthyl (R_S,S_C)-1-phenyl-1-(p-tolylsulfinylamino)-methanephosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-di-(1S,2R,5S)-menthyl (R_S,S_C)-1-phenyl-1-(p-tolylsulfinylamino)-methanephosphonate

There total 5 articles about (-)-di-(1S,2R,5S)-menthyl (R_S,S_C)-1-phenyl-1-(p-tolylsulfinylamino)-methanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(+)-O,O-di-(1S,2R,5S)-menthyl phosphite + (-)-(R)-N-(p-tolylsulfinyl)benzaldimine → (-)-di-(1S,2R,5S)-menthyl (RS,SC)-1-phenyl-1-(p-tolylsulfinylamino)-methanephosphonate (1567841-00-2)

Guidance literature:

(+)-O,O-di-(1S,2R,5S)-menthyl phosphite; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

(-)-(R)-N-(p-tolylsulfinyl)benzaldimine; In tetrahydrofuran; at -78 ℃; for 4h;

DOI:10.1002/hc.21130

Reference yield:

benzaldehyde (100-52-7) → (-)-di-(1S,2R,5S)-menthyl (RS,SC)-1-phenyl-1-(p-tolylsulfinylamino)-methanephosphonate (1567841-00-2)

Guidance literature:

Multi-step reaction with 2 steps

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 4 h / -78 °C

With lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1002/hc.21130

Reference yield:

(R)-p-toluenesulfinamide (247089-85-6) → (-)-di-(1S,2R,5S)-menthyl (RS,SC)-1-phenyl-1-(p-tolylsulfinylamino)-methanephosphonate (1567841-00-2)

Guidance literature:

Multi-step reaction with 2 steps

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 4 h / -78 °C

With lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1002/hc.21130

upstream raw materials:

(1S,2R,5S)-(+)-menthol

benzaldehyde

(R)-p-toluenesulfinamide

Downstream raw materials:

(S)-amino(phenyl)methylphosphonic acid