2-[4-(2-diphenylphosphanylnaphthalen-1-yl)quinazolin-2-yl]-2-methylpropionitrile

Base Information

Chemical Name:2-[4-(2-diphenylphosphanylnaphthalen-1-yl)quinazolin-2-yl]-2-methylpropionitrile
CAS No.:915969-48-1
Molecular Formula:C₃₄H₂₆N₃P
Molecular Weight:507.574
Hs Code.:

Synonyms:2-[4-(2-diphenylphosphanylnaphthalen-1-yl)quinazolin-2-yl]-2-methylpropionitrile

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Chemical Property of 2-[4-(2-diphenylphosphanylnaphthalen-1-yl)quinazolin-2-yl]-2-methylpropionitrile

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Technology Process of 2-[4-(2-diphenylphosphanylnaphthalen-1-yl)quinazolin-2-yl]-2-methylpropionitrile

There total 11 articles about 2-[4-(2-diphenylphosphanylnaphthalen-1-yl)quinazolin-2-yl]-2-methylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 915969-47-0
1-[2-(cyanodimethylmethyl)quinazolin-4-yl]naphthalen-2-yl trifluoromethanesulfonate

: 829-85-6
diphenylphosphane

: 915969-48-1
2-[4-(2-diphenylphosphanylnaphthalen-1-yl)quinazolin-2-yl]-2-methylpropionitrile

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; In N,N-dimethyl-formamide; at 100 ℃; for 43.5h;
DOI:10.1021/ol062023+

Reference yield:

: 915969-38-9
2-(1,1-dimethylallyl)quinazolin-4-ol

: 915969-48-1
2-[4-(2-diphenylphosphanylnaphthalen-1-yl)quinazolin-2-yl]-2-methylpropionitrile

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / PhNEt₂; POCl₃ / benzene / 2 h / Heating

2: 77 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 5 h / Heating

3: 97 percent / 4-methylmorpholine N-oxide; OsO₄ / acetone; H₂O / 96 h / 20 °C

4: 99 percent / aq. H₅IO₆ / CH₂Cl₂ / 3 h / 0 - 20 °C

5: NH₂OH*HCl; pyridine / ethanol / 2 h / Heating

6: Ac₂O / 4 h / Heating

7: 94 percent / AlBr₃; NaI / CH₂Cl₂ / 6.6 h / 0 - 20 °C

8: 96 percent / DMAP / CH₂Cl₂ / 5 h / 20 °C

9: 88 percent / NiCl₂(1,2-bis(diphenylphosphino)ethane); dabco / dimethylformamide / 43.5 h / 100 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminum tri-bromide; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; hydroxylamine hydrochloride; acetic anhydride; sodium carbonate; 4-methylmorpholine N-oxide; periodic acid; N,N-diethylaniline; sodium iodide; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/ol062023+

Reference yield:

: 915969-39-0
4-chloro-2-(1,1-dimethylallyl)quinazoline

: 915969-48-1
2-[4-(2-diphenylphosphanylnaphthalen-1-yl)quinazolin-2-yl]-2-methylpropionitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 5 h / Heating

2: 97 percent / 4-methylmorpholine N-oxide; OsO₄ / acetone; H₂O / 96 h / 20 °C

3: 99 percent / aq. H₅IO₆ / CH₂Cl₂ / 3 h / 0 - 20 °C

4: NH₂OH*HCl; pyridine / ethanol / 2 h / Heating

5: Ac₂O / 4 h / Heating

6: 94 percent / AlBr₃; NaI / CH₂Cl₂ / 6.6 h / 0 - 20 °C

7: 96 percent / DMAP / CH₂Cl₂ / 5 h / 20 °C

8: 88 percent / NiCl₂(1,2-bis(diphenylphosphino)ethane); dabco / dimethylformamide / 43.5 h / 100 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminum tri-bromide; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; hydroxylamine hydrochloride; acetic anhydride; sodium carbonate; 4-methylmorpholine N-oxide; periodic acid; sodium iodide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol062023+