(4-chlorophenyl)[3-(4-chlorophenyl)-1,6-dimethyl-1H-indazol-5-yl]methanone

Base Information

• Chemical Name: (4-chlorophenyl)[3-(4-chlorophenyl)-1,6-dimethyl-1H-indazol-5-yl]methanone
• CAS No.: 1381855-76-0
• Molecular Formula: C₂₂H₁₆Cl₂N₂O
• Molecular Weight: 395.288
• Mol file: 1381855-76-0.mol

Synonyms:(4-chlorophenyl)[3-(4-chlorophenyl)-1,6-dimethyl-1H-indazol-5-yl]methanone

Chemical Property of (4-chlorophenyl)[3-(4-chlorophenyl)-1,6-dimethyl-1H-indazol-5-yl]methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-chlorophenyl)[3-(4-chlorophenyl)-1,6-dimethyl-1H-indazol-5-yl]methanone

There total 5 articles about (4-chlorophenyl)[3-(4-chlorophenyl)-1,6-dimethyl-1H-indazol-5-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

[4-methyl-6-(N-methyl-N-nitrosoamino)-1,3-phenylene]bis[(4-chlorophenyl)methanone] (1381855-69-1) → (4-chlorophenyl)[3-(4-chlorophenyl)-1,6-dimethyl-1H-indazol-5-yl]methanone (1381855-76-0)

Guidance literature:

With acetic acid; zinc; In N,N-dimethyl-formamide; at 5 - 20 ℃;

DOI:10.1016/j.mencom.2012.05.020

Reference yield:

C22H17Cl2NO2 (1381855-60-2) → (4-chlorophenyl)[3-(4-chlorophenyl)-1,6-dimethyl-1H-indazol-5-yl]methanone (1381855-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; sodium nitrite / 20 °C

2: acetic acid; zinc / N,N-dimethyl-formamide / 5 - 20 °C

With acetic acid; zinc; sodium nitrite; In N,N-dimethyl-formamide;

DOI:10.1016/j.mencom.2012.05.020

Reference yield:

C21H15Cl2NO2 (1338356-34-5) → (4-chlorophenyl)[3-(4-chlorophenyl)-1,6-dimethyl-1H-indazol-5-yl]methanone (1381855-76-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1,2-dichloro-ethane / 48.5 h / 0 - 20 °C

2: water; sodium hydroxide / ethanol / 1 h / 80 °C

3: acetic acid; sodium nitrite / 20 °C

4: acetic acid; zinc / N,N-dimethyl-formamide / 5 - 20 °C

With water; acetic acid; sodium hydroxide; zinc; sodium nitrite; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/j.mencom.2012.05.020

upstream raw materials:

C₂₁H₁₅Cl₂NO₂

C₂₂H₁₇Cl₂NO₂

[4-methyl-6-(N-methyl-N-nitrosoamino)-1,3-phenylene]bis[(4-chlorophenyl)methanone]

C₂₂H₁₈Cl₂NO₂⁽¹⁺⁾*FO₃S^(1-)