1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Base Information

Chemical Name:1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one
CAS No.:1417531-46-4
Molecular Formula:C₃₇H₃₆F₄N₄O₂S
Molecular Weight:676.778
Hs Code.:

1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Synonyms:1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Chemical Property of 1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Technology Process of 1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

There total 13 articles about 1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417531-45-3
1-((5-(chloromethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

: 109-89-7
diethylamine

: 1417531-46-4
1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 1h; Reflux;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1417531-46-4
1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 12 steps

1: palladium diacetate; sodium carbonate / 1,2-dimethoxyethane; water / 3 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate; ethanol / 1 h / 20 °C / Cooling with ice

3: phosphorus tribromide / diethyl ether / 1.5 h / 20 °C / Cooling with ice

4: copper(l) iodide; tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 4 h / 40 °C / Inert atmosphere

5: triethylamine / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7: tetraethoxy orthosilicate / methanol / 5 h / Reflux

8: N,N-dimethyl-formamide / 4 h / 140 °C

9: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C

10: sodium tetrahydroborate; methanol / 0.5 h

11: thionyl chloride / dichloromethane / 1 h / Cooling with ice

12: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

With methanol; sodium tetrahydroborate; copper(l) iodide; thionyl chloride; tetraethoxy orthosilicate; ethanol; palladium diacetate; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; potassium iodide; In methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 90035-34-0
4-(4-trifluoromethylphenyl)benzaldehyde

: 1417531-46-4
1-((5-((diethylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 11 steps

1: sodium tetrahydroborate; ethanol / 1 h / 20 °C / Cooling with ice

2: phosphorus tribromide / diethyl ether / 1.5 h / 20 °C / Cooling with ice

3: copper(l) iodide; tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 4 h / 40 °C / Inert atmosphere

4: triethylamine / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6: tetraethoxy orthosilicate / methanol / 5 h / Reflux

7: N,N-dimethyl-formamide / 4 h / 140 °C

8: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C

9: sodium tetrahydroborate; methanol / 0.5 h

10: thionyl chloride / dichloromethane / 1 h / Cooling with ice

11: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

With methanol; sodium tetrahydroborate; copper(l) iodide; thionyl chloride; tetraethoxy orthosilicate; ethanol; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; potassium iodide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;