(8S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole

Base Information

Chemical Name:(8S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole
CAS No.:1046468-91-0
Molecular Formula:C₂₃H₂₃F₂N₃O₂
Molecular Weight:411.451
Hs Code.:

Synonyms:(8S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole

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Chemical Property of (8S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole

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Technology Process of (8S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole

There total 2 articles about (8S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 288315-03-7
3,3-difluoroazetidine hydrochloride

: 1046469-25-3
(8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxylic acid

: 1046468-91-0
(8S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole

Guidance literature:: (8S)-2,3-dimethyl-8-(2-methylphenyl)-3,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 40 ℃;

3,3-difluoroazetidine hydrochloride; In N,N-dimethyl-formamide; at 40 ℃;
DOI:10.1021/jm100040c